抗生素降阶梯疗法与传统抗生素治疗老年肺炎疗效及安全性比较

Effect and safety comparison between antibiotic de-escalation therapy and conventional antibiotic in the treatment of elderly pneumonia

目的对抗生素降阶梯疗法与传统抗生素治疗老年肺炎疗效及安全性进行分析比较。方法 80例老年肺炎患者按照随机数表法分为观察组和对照组,各40例,对照组给予传统抗生素治疗,观察组给予抗生素降阶梯疗法治疗,比较两组患者的二次感染发生率、治疗效果和住院时间等指标的差异。结果观察组患者临床治疗的总有效率(90.0%)高于对照组(75%),二次感染率(7.5%)低于对照组(27.5%),差异具有统计学意义(P<0.05);观察组静脉应用抗生素时间、感染控制时间、平均住院时间均低于对照组,差异有统计学意义(P<0.05)。结论抗生素降阶梯疗法治疗老年肺炎安全有效,促进了患者恢复。

Objective To analyze and compare effect and safety of antibiotic de-escalation therapy and conventional antibiotic in treatment of elderly pneumonia. Methods Diveided 80 cases of elderly pneumonia patients into observation group and control group according to a random number table method, 40 cases in each group, control group was treated with traditional antibiotic therapy, observation group was treated with antibiotic de-escalation therapy, the incidence of secondary infection, curative effect, hospitalization and so on were compared in two groups. Results Total effective rate of observation group（90.0%）was higher than that of the control group（75%）, incidence of secondary infection（7.5%） was lower than that of the control group（27.5%）, there was statistical significance（P〈0.05）, intravenous antibiotics time, infection control and hospitalization time of observation group were lower than control group, differences were statistically significant（P〈0.05）. Conclusion Antibiotic de-escalation therapy in the treatment of elderly pneumonia is safe and effective and can promote the recovery of patients.