摘要
【目的】观察冠心病及其不同分型患者血清中半乳糖凝集素-3（Gal-3）的水平，分析其与高敏 C反应蛋白（hs-CRP）、单核细胞趋化因子-1（MCP-1）的相关性，探讨 Gal-3在冠心病患者中的临床价值。【方法】收集经冠状动脉造影确诊的冠心病患者97例作为冠心病组，其中稳定性心绞痛组31例，不稳定心绞痛组35例，急性心肌梗死组31例，并收集冠脉造影正常的非冠心病患者30例作为对照组。采集入选病例一般临床资料，检测其血清 Gal-3、MCP-1及血浆 hs-CRP浓度。【结果】冠心病组血清 Gal-3水平明显高于对照组（P＜0．05），不稳定心绞痛组和急性心肌梗死组血清 Gal-3水平显著高于稳定性心绞痛组（P＜0．05），而急性心肌梗死组血清 Gal-3水平高于不稳定心绞痛组，但差异不具统计学意义（P ＞0．05）；冠心病患者血清 Gal-3水平与 hs-CRP、MCP-1水平显著正相关（P ＜0．05）。【结论】冠心病患者血清 Gal-3水平明显增高，血清Gal-3有望成为急性冠脉综合征新的生化标志物，具有重要的临床意义。联合检测 Gal-3、hs-CRP及 MCP-1对冠心病的早期诊断、危险分层及预后具有重要临床意义。
[Objective]To observe serum level of galectin-3（Gal-3）in patients with different types of coro-nary heart disease and analyze its correlation with high-sensitivity C-reactive protein（hs-CRP）and monocyte chemokine protein-1（MCP-1）,and to explore clinical value of Gal-3 in patients with coronary heart disease.[Methods]Totally 97 patients with coronary heart disease confirmed by coronary angiography were collected as coronary heart disease groups including stable angina pectoris group（group SA,n=31）,unstable angina pec-toris group（group UA,n=35）and acute myocardial infarction（group AMI,n=31）.Other 30 non-coronary heart disease patients with normal coronary angiography were collected as control group.General clinical data of all subjects were collected.Serum levels of Gal-3,MCP-1 and plasma hs-CRP were assayed.[Results]Ser-um Gal-3 level in coronary heart disease group was obviously higher that in control group（P0.05）. Serum Gal-3 level in patients with coronary heart disease was positively correlated with hs-CRP and MCP-1 significantly（P〈0.05）.[Conclusion]Serum Gal-3 level in patients with coronary heart disease is increased obviously,and may be a new biomarker for acute coronary syndrome,and has important clinical significance. Combined detection of Gal-3,hs-CRP and MCP-1 has important clinical significance in the early diagnosis,risk stratification and prognosis of coronary heart disease.
出处
《医学临床研究》
CAS
2014年第5期852-855,共4页
Journal of Clinical Research
