关节腔内注射玻璃酸钠治疗2型糖尿病合并膝骨性关节炎疗效分析

Analysis of the Efficacy of Intraarticular Injection with Hyaluronate Sodium for the Treatment of Type 2 Diabetes Mellitus with Knee Osteoarthritis

【目的】探讨玻璃酸钠关节腔注射治疗2型糖尿病（T2DM）合并膝骨性关节炎（KOA）的临床疗效。【方法】选取符合中度KOA诊断标准的80例患者为研究对象，其中单纯 KOA 40例（A组），T2DM合并KOA 40例（B组）。所有患者关节腔注射玻璃酸钠2 mL，1次/周，5次1个疗程。按膝关节功能评分标准（LKSS）评价疗效。【结果】A组：优20例（50％），良16例（40％），可3例（7．5％），差1例（2．5％），优良率为90．0％；B组：优12例（30％），良8例（20％），可15例（37．5％），差5例（12．5％），优良率为50％。两组优良率相比，差异有统计学意义（χ2＝15．238，P＜0．01）。【结论】玻璃酸钠关节腔注射治疗中度 KOA疗效确切，对 T2DM合并中度 KOA疗效欠佳。

[Objective]To explore clinical efficacy of intraarticular inj ection with hyaluronate sodium for the treatment of type 2 diabetes mellitus（T2DM）with knee osteoarthritis（KOA）.[Methods]Totally 80 patients ac-cording with diagnosis criteria of moderate KOA were enrolled in the study.Among them,40 patients were simple KOA（group A）and 40 patients were T2DM with KOA（group B）.All patients received intraarticular injection with hyaluronate sodium 2ml once a week.One course was 5 times.Knee joint function score standard（LKSS） was used to assess the efficacy.[Results]In group A,20 patients were excellent（50%）,and 16 patients were good（40%）,and 3 patients were fair（7.5%）,and 1 patient was poor（2.5%）,and the good and excellent rate was 90.0%.In group B,12 patients were excellent（30%）,and 8 patients were good（20%）,and 15 patients were fair （37.5%）,and 5 patients were poor（12.5%）,and the good and excellent rate was 50%.There was significant difference in the good and excellent rate between two groups（χ2=15.238,P〈0.01）.[Conclusion]Intraarticular inj ection with hyaluronate sodium for the treatment of moderate KOA has certain efficacy,but its efficacy is unsat-isfactory for T2DM with moderate KOA.