糖尿病足感染的病原菌特点及耐药性分析

Features and Drug Resistance of Pathogenic Bacteria in Diabetic Foot Infection

【目的】分析糖尿病足感染（DFI）病原菌分布情况及耐药情况，为合理选用抗菌药物提供依据。【方法】回顾性分析2011年1月至2013年6月本院收治的96例 DFI患者的病原菌培养及药敏资料。【结果】96例 DFI患者共培养出病原菌134株，其中革兰阳性（G＋）球菌74株（55．2％）、革兰阴性（G-）杆菌55株（41．0％）、真菌5株（3．7％）。G-球菌主要有金黄色葡萄球菌、表皮葡萄球菌、肠球菌，G-杆菌则主要包括大肠埃希菌、肺炎克雷伯杆菌、铜绿假单胞菌。其中，G＋球菌对克拉霉素及红霉素耐药情况严重。G-杆菌中铜绿假单胞菌对多种抗生素耐药严重。【结论】DFI患者应及早、多次的行病原学检查，合理选用抗生素，才能有效控制感染。

[Objective]To analyze the distribution and drug resistance of pathogenic bacteria in diabetic foot infection in order to provide a basis for reasonable application of antibiotics.[Methods]The data of pathogenic bacteria culture and drug sensitivity of 96 patients with diabetic foot infection in our hospital from Jan.2011 to June 2013 were analyzed retro-spectively.[Results]The 134 strains of pathogenic bacteria in 96 patients with diabetic foot infection were isolated.A-mong them,74 strains were Gram-positive bacteria（55.2%）,and 55 strains were Gram-negative bacteria（41.0%）,and 5 strains were fungi（3.7%）.Common positive coccobacteria were staphylococcus aureus,staphylococcus epidermidis and enterococcus faecalis,while common negative bacteria were Escherichia coli,Klebsiella pneumoniae and pseudomonas aeruginosa.Positive coccobacteria were severely resistant to clarithromycin and erythromycin,while pseudomonas aerugi-nosa in negative bacteria were severely resistant to multiple antibiotics.[Conclusion]For patients with diabetic foot infec-tion,early and multiple etiological examination should be taken.Reasonable selection of antibiotics can control diabetic foot infection effectively.