VEGF在宫颈小细胞神经内分泌癌组织中表达及意义

Expression and Significance of VEGF in Small Cell Neuroendocrine Carcinoma of Cervix

【目的】探讨血管内皮生长因子（VEGF）在宫颈小细胞神经内分泌癌组织（SCNC）中表达及意义。【方法】收集宫颈鳞癌（SCC）患者23例标本（SCC组）、SCNC患者23例标本（SCNC组）及正常宫颈23例标本（对照组），三组均采用免疫组织化学技术检测VEGF表达，并分析其表达与SCNC临床病理指标的相关性和生存时间。【结果】对照组、SCC组、SCNC组中 VGFR 的阳性率分别为0％、52．2％、82．6％，三组比较有统计学意义（P＜0．05）；VEGF高表达与 SCNC临床分期、病理亚型、肌层侵犯程度有关（P＜0．05）；VEGF表达阴性患者3年生存率75％显著高于表达阳性的3年生存率（15．8％），其差异有统计学意义（P ＜0．05）。【结论】VEGF高表达可能与 SCNC的强侵袭性生物学特点有关，可作为 SCNC的诊断及预后判断提供依据。

[Objective]To explore the expression and significance of VEGF in small cell neuroendocrine carcinoma of cervix（SCNC）.[Methods]The specimens of 23 patients with squamous carcinoma of cervix （SCC）（group SCC）,23 SCNC patients（group SCNS）and 23 patients with normal cervix（control group）were collected.Immunohistochemistry method was used to detect the expression of VEGF in 3 groups.The correla-tion between VEGF expression and clinical pathological indexes of SCNC and survival time were analyzed.[Re-sults]The positive expression rates of VEGF in control group,SCC group and SCNC group were 0%,52.2%and 82.6% respectively,and there was significant difference among 3 groups（P〈0.05）.High expression of VEGF was correlated with clinical stage,pathological subtypes and muscular invasion（P〈0.05）.The 3-year survival rate of patients with negative expression of VEGF was 75%,which was markedly higher than that of patients with positive expression of VEGF （15.8%）,and there was significant difference （P 〈0.05 ）.[Conclusion]High expression of VEGF may be associated with biological characteristics such as the strong in-vasion,and can provide the evidence for the diagnosis and prognosis of SCNC.