早期鼻腔NK/T细胞淋巴瘤三组放射治疗剂量的效果比较

Comparison of effect of three radiation doses for early stage nasal NK /T cell lymphoma

目的探讨放疗剂量对早期鼻腔NK／T细胞淋巴瘤预后的影响。方法将64例早期鼻腔NK／T细胞淋巴瘤患者，根据放疗剂量大小分为〈50Gy组（n=20），51～60Gy组（n=24）和〉60Gy组（n=20），观察比较各组局部控制率和5年生存率。结果经随访〈50Gy组局部控制率68．5％，5年生存率42．1％。51～60Gy组局部控制率达到82．5％，生存率达60．9％。两组对比在局部控制率和5年生存率有统计学意义（P〈0．05），但51—60Gy组和〉60Gy组对比无统计学意义。结论以51—60Gy剂量的放疗能保证良好的局部控制率，提高患者总生存率，建议临床在选择放疗剂量时以51—60Gy为宜。

Objective To study the effects of different radiotherapy doses on the early stage nasal NK/T cell lymphoma. Methods 64 patients with early stage nasal NK/T cell lymphoma undergoing radiotherapy were divided into 〈 50 Gy group （ n = 20）, 51-60 Gy group（n =24） and 〉60 Gy group（n =20） , all groups were observed and their local control rate and survival rate of 5 years were compared. Results The total local control rates in the three groups were 68.5%, 82.5% and 72.2% respectively. There was significant difference in the local control rate and survival rate of 5 years between 〈 50 Gy group and the other two groups 51-60 Gy and 〉 60 Gy group） （P 〈 0.05 ）, but the differences between the two groups were not statistically significant. Conclusions 51-60 Gy doses of radiation can guarantee good local control rate, improve overall survival rate. The choice of radiation doses to 50 Gym patients with early stage nasal NK/T cell lymphoma is appropriate, with clinical recommendations.