epiregulin在涎腺腺样囊性癌组织中的表达及其与临床病理特征的关系

Expression of epiregulin in tissue of salivary adenoid cystic carcinoma and its relationship with clinicopathological characteristics

目的探讨表皮生长因子epiregulin在涎腺腺样囊性癌(salivary adenoid cystic carcinoma,SACC)肺转移中的作用。方法 SACC石蜡组织标本30例。通过免疫组织化学方法(SP方法)检测epiregulin在SACC石蜡组织标本中的表达,并分析其与临床病理特征之间的关系。结果 (1)Epiregulin广泛地表达于细胞质或细胞核。(2)SACC发生肺转移15例,阳性着色率86.7%(13/15),H-score(Hs)定量分析平均为1.26±0.65;未发生肺转移15例,阳性着色率33.3%(5/15),Hs为0.48±0.25。与Ⅰ+Ⅱ期相比,epiregulin在SACCⅢ+Ⅳ期表达显著升高。(3)Kaplan-Miere生存曲线分析未发现epiregulin的表达与SACC患者的预后相关。结论 Epiregulin的表达与涎腺腺样囊性癌肺转移有一定相关性,但仍需要大样本研究进一步证明。

Objective To study the role of epiregulin, a member of epidermal growth factor （EGF） family, in the metastasis of salivary adenoid cystic carcinoma （ SACC ） cell. Methods Thirty paraffin-embeded archival tissue samples were used to examine epiregulin expression in SACC tissue by immunohistochemistry SP methods. Its relationship with clinicopathological characteristics were analyzed afterwards. Results （ 1 ） Epiregulin expressed broadly in cytoplasm or nuclear compartments. （ 2 ） The epiregulin positive stain rate in lung metastasis-group （15 cases） was 86.7% （13/15） , its average H-score is 1.26 ±0.65, whereas for non-metastasis group, the positive stain rate was 33.3% （5/15）, and H-score was 0.48 ± 0.25 on average. Epiregulin expressed higher in stage Ⅲ and Ⅳ than in clinical stages of Ⅰ and Ⅱ. （3）No correlation was found between epiregulin expression and survival. Conclusions Epiregulin expression may be associated with SACC lung metastasis. Studies of large sample size to further confirm the findings of this pilot study is warranted.