利巴韦林、炎琥宁注射液治疗婴幼儿轮状病毒肠炎的疗效分析

The Clinical Effect Analysis of Patients with Infantile Rotavirus Enteritis Treated by Ribavirin,Yanhuning

目的:观察利巴韦林、炎琥宁治疗婴幼儿轮状病毒肠炎的临床疗效。方法:将我院诊疗的婴幼儿轮状病毒肠炎患者236例随机分为利巴韦林组(A组)、炎琥宁组(B组)、对照组(C组),再按入院时距发病时间分为病程0-48 h组,病程>48 h组。C组仅给予补液、维持水电解质平衡等基础治疗;A组加用利巴韦林(10-15)ng/(kg·d)静脉滴注,B组加用炎琥宁(5-8)mg/(kg·d)静脉滴注,比较各组患儿发热持续时间、退热时间、腹泻性状及次数恢复正常时总病程时间。结果:在病程0-48 h组中,A组、B组的退热时间均明显短于C组,B组总病程明显短于C组,P均<0.05;在病程>48 h组中,A组、B组、C组退热时间均无明显差异,B组总病程短于A组、C组。结论:在起病0-48 h间使用利巴韦林、炎琥宁有助于轮状病毒肠炎患者退热,使用炎琥宁可缩短病程,有助于改善腹泻症状。

Objective：To observe the clinical effect of Ribavirin and Yanhuning for patients with infantile rotavirus enteritis. Method： 236 patients with infantile rotavirus enteritis were randomly divided into Ribavirin group （group A）,Yanhuning group （group B）and control group （group C）. Among the three groups, there were divided into 0-48 h group and 〉 48 h group according the onset time to in-hospital. Based on the group C granted rehydration, maintain water and electrolyte balance, group A was given Ribavirin （10-15） mg/ （kg.d）, intravenous drip, group B was given Yanhuning （5-8） mg/（,kg.d）, intravenous drip. The fever duration, fever to normal time, number of traits and diarrhea, the overall course were compared among the three groups. Results： At the 0-48 h groups, antifebrile time in both the group A and group B were significantly shorter than that in the group C, overall duration in group B was significantly shorter than that in the group C, all P 〈 0.05. At the 〉 48 h groups, antifebrile time in the three groups were no significant difference, but overall duration in group B was shorter than that in the other two groups. Conclusion： Using Ribavirin and Yanhuning can help antifebrile for patients with infantile rotavirus enteritis during the onset 0-48 hours, and Yanhuning may short the overall duration and help to improve symptoms of diarrhea for the cases.