慢性乙型肝炎抗病毒治疗依从性影响因素分析

Analysis on influence factors of antiviral therapy compliance in chronic hepatitis B cases

目的探讨慢性乙型病毒性肝炎患者用药依从性的影响因素。方法以服药依从性差的32例患者为观察组；服药依从性好的32例患者为对照组。采用Logistic回归分析方法，探索影响慢性乙型肝炎患者服药依从性的因素。结果与服药依从性差的患者相比，服药依从性好的患者组中有乙肝家族史（OR0．042，95％C．I．0．005～0．333）、抗病毒治疗的认知程度高（OR 0．112，95％C．I．0．014～0．872）和“医师告知”详细（OR0．142，95％C．I．0．020～0．993）的出现服药依从性差的危险度均降低。结论有乙肝家族史的患者，可从亲属的诊疗经历中获得经验，而服药依从性较好。此外，医师加强对患者“治疗认知度”的培训，可提高患者抗病毒治疗的依从性。

Objective To analyze the factors which influenced medication compliance of patients with chronic hepatitis B （CHB）, so as to improve the treatment compliance of patients. Methods 32 pa- tients with poor compliance were recruited as the observation group, 32 patients with good compliance were selected as the control group. The multivariate logistic regression model was used to investigate the potential correlative factors that influenced the medication compliance of the case. Results Compared with poor med- ication compliance of patients, the good medication compliance of patients, who had family history of hepati- tis B （OR 0. 042, 95% CI 0. 005-0. 333 ） , learned more about the content of the antiviral treatment （OR 0. 112, 95% CI 0. 014-0. 872） , and got more information from physicians （ OR 0. 142, 95% CI 0. 020- 0. 993 ） , showed poor compliance risk reduction. Conclusions The patients who had family history of hep- atitis B can gain more message from the relative experience of treatment. Their medication compliance were better. Future work should focus on health education to improve the compliance of patients receiving antiviral therapy.