一种基于稳态光子计数模式的面向乳腺扩散荧光-光学联合层析成像方法

A combined diffuse fluorescence and optical tomography of steadystate photon-counting mode for breast tumor diagnosis

为增强乳腺扩散光学层析(Diffuse Optical Tomography,DOT)方法的实用性,提出了一套稳态扩散荧光-光学联合断层成像系统与算法.系统采用基于光开关切换的串-并混合门控光子计数检测模式,可有效实现测量时间、灵敏度和系统性价比之间的平衡;算法以图形处理器加速的蒙特卡洛光子输运模型为基础,采用了荧光DOT"导航"的血氧DOT图像重建策略,通过利用高对比度荧光DOT的先验位置信息,可有效改善血氧DOT图像重建的不适定性.仿体实验结果表明,与单独DOT方法相比,此联合方法可明显提高图像重建的定位准确度和定量性.

A combined fluorescence-optical tomography methodology of steady-state is developed to enhance the applicability of the breast-dedicated diffuse optical tomography （DOT）. The system employed a 4-channel gated photon-counting technique working in a fiber-switch-based tandem series-to-parallel mode to achieve the tradeoff among the measuring time, probing sensitivity and cost effectiveness. Based on the graphics-processing-unit accelerated Monte Carlo modeling of photon migration, a fluorescence-guided hemoglobin DOT reconstruction algorithm was proposed, which can effectively alleviate the ill-posedness of the hemoglobin DOT using the localization prior provided by the high-contrast fluorescence DOT. The phantom experiments demonstrate that the reconstruction accuracy and quantitative performance can be improved efficiently comparing with the standalone-DOT.