术前长期服用阿司匹林对脑出血术后再出血影响的回顾性队列研究

Effect of Preoperative Long-term Use of Aspirin on Postoperative Rehaemorrhagia of Cerebral Hemorrhage

目的:探讨术前长期服用阿司匹林对脑出血术后再出血的影响。方法:采用回顾性队列研究方法,62例曾接受脑出血开颅手术治疗的患者,分为暴露组(术前长期服用阿司匹林)32例和非暴露组(术前未长期服用阿司匹林)30例,比较两组术后再出血情况(包括术后再出血量及出血率)及预后转归情况(包括两组患者死亡率及术后6个月日常行为能力评估)。结果:暴露组患者术后出血量为(57.63±14.01)ml,高于非暴露组患者出血量(40.52±12.92)ml(P<0.05);暴露组死亡率为37.5%,高于非暴露组的12.5%(P<0.05);暴露组术后6个月Barthel评分为(52.16±6.34)分,低于非暴露组的(69.42±6.02)(P<0.05)。结论:术前长期服用阿司匹林可增加脑出血术后再出血的发生率和致残率。

Objective：To investigate the effect of preoperative long-term use of aspirin on postoperative rehaemorrhagia of cerebral hemorrhage. Methods： 62 patients receiving surgical operation treatment for the treatment of cerebral hemorrhagea were divided into the exposed group （ taking aspirin before operation） with 32 cases and non-exposed group （ without taking aspirin before operation） with 30 cases. And then the postoperative hemorrhage of the two groups （ including the amount of postoperative bleeding and bleeding rate） and the prognosis of the patients （including mortality and daily behavior ability of patients 6 months after operation） were compared. Results：The postoperative hemorrhage volume of patients in the exposed group and non-exposed group were （57.63 ± 14.01 ）ml and（40.52 ± 12.92 ）ml, respectively. When compared, the postoperative hemorrhage volume of the exposed group were higher than that of the control group, and the difference was statistically significant （P 〈0.05 ）. The mortality of the exposed group was 37.5%, higher than that of the control group（ 12.5% ） ,and the difference was statistically significant （P 〈0.05）. Barthel scores of the exposed group for the postoperative 6 months were （52.16 ±6.34） points, lower than those of the non-exposed group （69.42 ±6.02）, and the difference was statistically significant （ P 〈 0.05 ）. Conclusion： Preoperative long-term use of aspirin could increase the incidence of rehaemorrhagia after the operation of cerebral hemorrhage and postoperative mortality and morbidity.