摘要
目的:探讨姜黄素(Cur)与格列本脲(Gli)联用对2型糖尿病大鼠糖代谢的影响及其机制。方法:复制大鼠2型糖尿病模型,观察Cur(100 mg·kg-1·d-1ig)×5 d单用及与Gli(1 mg·kg-1·d-1ig)×5 d联合应用对2型糖尿病大鼠空腹血糖、血浆胰岛素、胰岛素敏感性指数、肝糖原、肝毒性相关指标以及CYP3A活性的影响。结果:Cur能进一步增强Gli的降糖作用,应用Cur后比单用Gli进一步降低空腹血糖(22%至69%),上调胰岛素及肝糖原水平(49%、19%至126%、81%)。Cur可显著下调肝损伤指标,对肝脏具有保护作用。Cur单用或与Gli联用均显著抑制CYP3A活性。结论:Cur可使Gli降糖效应增强,其机制可能与其抑制Gli代谢酶-CYP3A活性,使Gli代谢延缓,致使其降糖效应增强有关。
Objective：To investigate the effects and mechanism of combination therapy with curcumin （Cur） and glibenclamide （Gli） on glucose metabolism in type 2 diabetic rats.Methods：The model of type 2 diabetic rats was established except the control group.Cur （100mg · kg^-1 · d^-1） and/or Gli（1 mg · kg^-1 · d^-1） was given to the type 2 diabetic rats for 5 consecutive days.The fasting plasma glucose（FPG）,plasma insulin（Ins）,insulin sensitivity index （ISI）,hepatin hepatotoxicity indices and the activities of CYP3A were measured.Results：After the treatment of Cur ＋ Gli,FPG was reduced,Ins and hepatin were increased compared with Gli-treated group.The activities of CYP3A and the markers of liver injury were significantly decreased in the rats treated with Cur and Cur ＋ Gli.Conclusion：Cur can enhance the hypoglycemic effect of Gli,which may be related with the inhibition of the activities of CYP3A.
出处
《中国药师》
CAS
2014年第6期912-915,共4页
China Pharmacist
