摘要
目的:筛选金樱子醇提取物颗粒剂的制备工艺。方法:通过综合评分法确定颗粒剂的最佳辅料比,设计L9(34)正交试验,以粒度为评价指标确立处方工艺,并在此基础上考察了临界相对湿度。结果:该颗粒剂采用湿法制粒,最佳处方组成为稠膏-乳糖-可溶性淀粉-10%淀粉浆(5∶12∶3∶0.6)。结论:该颗粒成型性好,相对临界湿度符合生产要求。
Objective：To screen the preparation process of Rosa laevigata Michx ethanol extract granules.Methods：The optimal ratio of the adjuvants was obtained by comprehensive scoring method.The optimal formula and preparation conditions were screened by L9 （34） orthogonal tests with particle size as the index,and the critical relative humidity （CRH%） was investigated as well.Results：The granules were prepared by wet granulation with the optimal formula of extract-lactose-soluble starch-10% starch slurry （5∶ 12∶ 3∶0.6）.Conclusion：The formula and preparation technology are stable,and the CRH% meets the requirements of industrial production.
出处
《中国药师》
CAS
2014年第6期945-947,共3页
China Pharmacist
基金
2012年度湖南省大学生研究性学习和创新性实验计划项目(编号:湘教通[2012]402号)
