市售保泰松片溶出度方法的考察

Study on Dissolution of Marketed Phenylbutazone Tablets

目的:建立保泰松片溶出度的检测方法。方法:从溶出方式、溶出介质、转速3个因素考察,紫外分光光度法测定,对不同厂家批次的保泰松片的溶出曲线进行对比研究。结果:采用桨法,以pH6.8磷酸盐缓冲液为溶出介质,转速为100 r·min-1,考察市售保泰松片的溶出度。结论:此方法准确、可靠,可用于评价保泰松片的质量。

Objective：To establish a method for the dissolution determination of phenylbutazone tablets.Methods：Comparison of dissolution curves for different batches of phenylbutazone tablets was presented by UV spectrophotometry with three factors,including the dissolution mode,medium and speed.Results：The dissolution determination conditions of phenylbutazone tablets were as follows：an oar method was used with the stiring speed of 100 r · min-1,and the dissolution medium was pH 6.8 phosphate buffer.Conclusion：The method is accurate and reliable,and can be used to evaluate the quality of phenylbutazone tablets.