复方阿莫西林干混悬剂溶出度的测定

Dissolution Determination of Compound Amoxicillin Dry Suspensions

目的：建立复方阿莫西林干混悬剂溶出度测定方法.方法：以乙酸铵缓冲液为溶出介质,采用紫外分光光度法测定复方阿莫西林干混悬剂的溶出度.结果：阿莫西林和盐酸氨溴索的线性范围分别为65～260 μg·ml-1（r =0.999 1）和4.25～29.75 μg·ml-1（r=0.9992）,回收率分别为99.31％和98.43％,RSD分别为0.48％和1.08％（n=9）.结论：该方法简单易行,可用于复方阿莫西林干混悬剂的溶出度测定.

Objective：To establish a dissolution determination method for compound amoxicillin dry suspensions.Methodss：The dissolution was determined by UV using ammonium acetate buffer as the dissolution medium.Result：The linear range of amoxicillin and ambroxol was 65 ～ 260 μg · ml-1 （r =0.999 1） and 4.25-29.75 μg · ml-1 （r =0.999 2）,respectively.The recovery was 99.31% and 98.43% with RSD of 0.48% and 1.08% （n =9）,respectively.Conclusion：The method is simple and can be used in the dissolution determination of compound amoxicillin dry suspensions.