替米沙坦联合氨氯地平对糖尿病合并高血压患者血糖、血脂的影响

Effect of Telmisartan Combined with Amlodipine on Serum Glucose and Lipids in Patients with Type 2 Diabetes Mellitus and Hypertension

目的:观察替米沙坦联合氨氯地平对糖尿病合并高血压患者血糖、血脂的影响。方法:将符合纳入标准的80例门诊糖尿病合并高血压患者随机分为联合治疗组(替米沙坦40 mg联合氨氯地平2.5 mg,均po,qd)40例及单药治疗组(氨氯地平5 mg,po,qd)40例。观察治疗前及治疗16周后患者血压、血脂及血糖变化。结果:联合治疗组治疗后空腹血糖、三酰甘油较前有明显下降,且与单药治疗组比较差异有统计学意义(P<0.05)。联合治疗组治疗后低密度脂蛋白胆固醇较前明显下降,但与单药治疗组相比差异无统计学意义。结论:替米沙坦联合氨氯地平治疗糖尿病合并高血压患者,在降压的同时能改善血糖、血脂水平,有较好的应用前景。

Objective：To investigate the effect of telmisartan combined with amlodipine on serum glucose and lipids in patients with type 2 diabetes mellitus and hypertension.Methods：Totally 80 patients with type 2 diabetes and hypertension were divided into the observation group and the control group.The observation group was given 40mg telmisartan combined with 2.5mg amlodipine and the control group was treated by 2.5mg amlodipine,po,qd.After four-month treatment,the blood pressure,blood glucose and serum lipids were observed and compared between the two groups.Results：The levels of fasting blood sugar and TG of the observation group were significantly lower than those of the control group （P 〈 0.05）.Although LDL-C was decreased in the observation group,no significant difference was detected between the two groups.Conclusion：Telmisartan is effective in improving the level of serum glucose and lipids in patients with diabetes mellitus and hypertension.