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米非司酮片对早孕绒毛中IGF-II及MMP-9表达的影响

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摘要 目的探讨米非司酮片预处理后早孕绒毛中胰岛素样生长因子-II(IGF-II)和基质金属蛋白酶-9(MMP-9)的表达。方法采用实时荧光定量PCR技术检测20例正常早孕妇女和10例米非司酮片预处理早孕妇女绒毛组织中IGF-II mRNA及MMP-9 mRNA的表达量。结果米非司酮片预处理组绒毛中IGF-II mRNA的表达水平低于对照组,但差异无统计学意义(P>0.05),MMP-9 mRNA的表达水平明显低于对照组,差异有统计学意义(P<0.01)。结论米非司酮片预处理后早孕绒毛中MMP-9表达明显降低,IGF-II表达虽降低,但差异无明显统计学意义。
作者 张旭东
出处 《泰山医学院学报》 CAS 2014年第5期418-419,共2页 Journal of Taishan Medical College
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  • 1Tao L, Suhua C, Juanjuan C, et al. In vitrostuday on human cyto- megalovirus affecting early pregnancy villous EVT" s invasion func- tion[J]. Virol J,2011,8:114.
  • 2Lioannidis 1, Dimo B, Karamefis A, et al. Comparative study of the immunohistochemical expression of metaiioproteinases 2, 7and 9 between clearly invasion carcinomas " in situ" tmphoblast invasion [J]. Neoplama, 2010,57( 1 ) :20,28.
  • 3Thomsen BM, ClausenHV, Larsen LG, et al. Patterns in expres- sion of insulin-like growth Factor- 11 and ofproliferative activity in- the normal human first and third trimester placenta demonstrated bynon-isotopic in situ hybridization and immunohistoehemieal stai- ning forMIB-1 [J]. Placenta, 1997, 18: 145- 154.
  • 4Isaka K, Usuda S, Ito H, eta. 1 Expression and activity of matrix- metalloproteinase 2 and 9 in human tmphoblasts[J]. Placenta, 2003, 24(1) : 53 -64.
  • 5Singh M, Kindelberger D, Nagymanyoki Z, et al. Matrix metallo- Proteinase and their inhibitors and inducer in gestational tmpho- blastic diseases and normal placenta [ J ]. Gynecologic ontology, 2011,122( 1 ) :178 - 182.
  • 6Thomsen BM, Clausen HV, Ursen LG,et al. Patterns In expression of insulin-likegrowth factor-11 and of proliferative activity in the normal human first and third trimester placenta demonstrated by non-isotopic in situ hybridization and immunohistoehemieal stai- ning for MIB - 1 [ J ]. Placenta, 1997,18 : 145 - 154.

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