四磨汤口服液对胃癌术后辅助化疗胃肠道反应的影响

Influence of SiMoTang Oral Liquid on Gastrointestinal Responses of the Patients with Adjuvant Chemotherapy after the Surgery of Gastric Cancer

目的:观察四磨汤口服液对胃癌术后化疗所致胃肠道反应的影响。方法:将55例患者随机分为2组,治疗组23例在化疗开始时口服四磨汤,1剂/d,连续服用5天;对照组22例,根据化疗过程中出现的毒副反应给予对症处理。结果:治疗组化疗后恶心、呕吐、便秘、腹胀发生率较对照组明显降低(P<0.05),食欲下降率较对照组低(P<0.05)。Ⅱ级以上胃肠道毒副反应发生率明显低于对照组(P<0.05)。Kamofsky评分治疗组治疗后增高,对照组治疗后降低,2组比较差异显著(P<0.05)。结论:四磨汤口服液能明显减轻胃癌术后化疗所致的胃肠道反应,使患者获得更多的治疗机会,提高生存率。

Objective：To observe the effects of SiMoTang oral liquid on gastrointestinal responses of the pa-tients with chemotherapy after the surgery of gastric cancer. Methods： All 55 patients were randomized into two groups, 23 cases of the treatment group began to take SiMoTang when the chemotherapy was started, one dose per day, for five consecutive days;22 cases of the control group were administered with corresponding treatment accord-ing to adverse reaction in the course of the chemotherapy. Results：The treatment group was obviously less than the control group after chemotherapy in the incidences of nausea, vomiting, constipation and abdominal distention （P〈0.05）, lower than the control group in the decrease rate of the appetite （P〈0.05）. The incidence of gastrointestinal respons-es above gradeⅡof the treatment group was lower significantly than that of the control group （P〈0.05）. Kamofsky score in the treatment group was increased after treating, and it was decreased in the control group, the difference was significant （P〈0.05）. Conclusion：SiMoTang oral liquid could remarkably alleviate gastrointestinal responses in-duced by the chemotherapy after the surgery of gastric cancer, which could make the patients obtain more opportuni-ties for treatment and improve survival rate.