TET2基因在血液系统疾病中的研究进展

TET2 Gene in Hematological Diseases——Review

几年前发现了TET基因家族。最近研究表明,TET2(TET基因家族成员2)在DNA去甲基化修饰、表观遗传调控及骨髓造血中扮演着重要角色,在一系列骨髓恶性肿瘤中,包括骨髓增殖性肿瘤、骨髓增生异常综合征及白血病也检测到TET2突变,揭示了TET2肿瘤抑制基因的作用。本文对TET2基因在血液系统疾病中的研究进展作一综述,包括TET基因的表观遗传调控功能,TET2基因与骨髓造血调控和TET2基因与血液系统疾病等问题。

The TET gene family has been found a few years ago. Recent studies indicated that TET2 （ TET gene family 2） plays an important role in DNA demethylation, the epigenetic regulation and normal hematopoiesis. TET2 mutation has been discovered in a spectrum of myeloid malignancies, including myeloproliferative neoplasms （MPN）, myelodysplastic syndrome （MDS） and leukemia, which suggest the role of TET2 as a tumor suppressor. In this review the recent results implicating TET2 in hematological malignancies are summarized, including regulatory fuctions of TET gene epigenetics, TET2 gene and hematopoietic regulation in bone marrow, TET2 gene and hematological disease （MPN, MDS, AML, CMML, lymphoma） and so on.