IL-17和Th17细胞在移植物抗宿主病中的免疫调控作用

Immunoregulatory Effects of Interleukin-17 and Th17 Cells in Graftversus-Host Disease——Rewiew

异基因造血干细胞移植是有望治愈血液系统疾病、部分先天性疾病和自身免疫性疾病等的方法,但移植物抗宿主病(graft-versus-host disease,GVHD)是异基因造血干细胞移植后的重要并发症,并引发受者死亡,直接影响移植效果。众多免疫细胞和炎症因子参与了GVHD的发生,近年来发现的一类新的CD4+IL-17+T细胞(Th17细胞),IL-17和Th17细胞成为了感染免疫、自身免疫性疾病、肿瘤免疫和GVHD研究领域的热点。本文就IL-17和Th17细胞在GVHD免疫调控中的作用作一综述。

Allogeneic hematopoietic stem cell transplantation （allo-HSCT） is an intensive therapy to cure high-risk haematological malignant disorders, congenital diseases, autoimmune disease and so on. The main complication of HSCT is graft-versus-host disease （GVHD）, which can cause the death of recepients and affect the therapeutic effect. Many kinds of immune cells and inflammatory factors were involved in the occurrence of GVHD. Twenty years ago the mice and human interleukin-17 （IL-17） were found. A new kind of T cell-CD4· IL-17 · T was found in recent years, named Th17 cells. Now IL-17 and Thl7 cells have become the hot spot in the research field of infection immunity, autoimmune diseases, tumor immunity and GVHD. In this article, immunoregulatory effects of interleukin-17 and Th17 cells in GVHD are reviewed.