芪苈强心胶囊对冠心病合并心力衰竭患者血清脂联素水平及心功能的影响

Effects of Qili Qiangxin capsule on serum concentration of adiponectin and heart function in patients with coronary heart disease combined with congestive heart failure

目的:探讨芪苈强心胶囊对冠心病合并心力衰竭患者血清脂联素(APN)、氨基末端脑钠肽前体(NT-proBNP)水平及心功能的影响。方法:将120例冠心病合并心力衰竭患者随机分为对照组和治疗组,在西医常规治疗基础上分别加用对照胶囊和芪苈强心胶囊,疗程6个月。观察治疗前后患者的心功能分级,超声心动图下测定左心室舒张末期内径(LVEDD)、左心室收缩末期内径(LVESD)和左心室射血分数(LVEF),测量患者6 min步行距离(6-MWT),酶联免疫法测定血清APN和NT-proBNP水平变化。结果:心衰患者的血清APN和NT-proBNP水平随着美国纽约心脏协会(NYHA)分级增加而明显升高;治疗6个月后,治疗组和对照组治疗总有效率分别为91.7%和75.0%,差异有统计学意义(P<0.01)。治疗后2组患者LVEDD和LVESD均缩小,LVEF明显提高,6-MWT明显增长,血清APN和NT-proBNP水平均降低,与对照组比较,治疗组以上指标改善更为显著,差异有统计学意义(P<0.05)。结论:芪苈强心胶囊可以显著降低冠心病合并心力衰竭患者的血清APN和NT-proBNP水平,明显改善心功能。

AIM：To investigate the effects of Qili Qiangxin capsule on serum adiponectin （ APN） , serum Nterminal probrain natriuretic peptide （ NT-proBNP） and heart function in the patients of coronary heart disease combined with congestive heart failure .METHODS： One hundred and twenty patients were randomly divided into treatment group and control group , and both groups were given anti-failure routine therapy .The patients in treatment group were treated with Qili Qiangxin capsule and the patients in control group were treated with placebo .The patients in the 2 groups were given a certain dose of the drugs for 6 months.The New York Heart Association （NYHA） heart function classification, left ventricular end-diastolic diameter （LVEDD）, left ventricular end-systolic diameter （LVESD）,left ventricular ejection fraction （LVEF）, and 6-min walking test （6-MWT） were observed before and after treatment .The levels of APN, NT-proBNP were measured by ELISA before and after treatment .RESULTS：With the increase in the class of NYHA heart function , the serum concentrations of APN and NT-proBNP in the heart failure cases increased significantly .After 6-month treatment, the effective rate in experimental group was 91.7%and that in control group was 75.0%.A significant difference was found between the 2 groups （P〈0.01）.After treatment, LVEDD and LVESD in both groups were decreased significantly, and LVEF in both groups was increased significantly .The serum concentrations of APN and NT-proBNP decreased significantly （P〈0.05）.6-MWT result was improved significantly.Compared with control group, more obvious effect was observed in experimental group （ P〈0.05） .CONCLUSION：Treatment with Qili Qiangxin capsule reduces the levels of APN and NT-proBNP in the patients with coronary heart disease combined with congestive heart failure .