伴淋系抗原表达的急性髓系白血病特点及临床意义

Characteristics and clinical significance of acute myeloid leukemia with lymphoid lineage antigen

目的探讨急性髓系白血病(acute myeloid leukemia,AML)中淋系抗原表达的特点及临床意义。方法应用流式细胞术(flow cytometry,FCM)检测106例初诊AML患者的免疫表型。结果①106例AML中伴淋系抗原表达者占58.49%(62/106)。②CD56+AML、Ly≥2+AML的完全缓解(complete remission,CR)率及无复发生存期(relapse free survival,RFS)与Ly-AML比较,均有显著性差异(P<0.05)。③CD7+AML、CD19+AML的CR率及RFS与Ly-AML组比较,均无显著性差异(P>0.05)。结论伴有CD56表达或多个淋系抗原表达的AML预后较差。

Objective To study the feature of lymphoid lineage antigen in acute myeloid leukemia （AML） and its clinical significance. Methods Immunophenotype was performed in 106 AML patients by three-color flow cytometry. Results （1）In 106 cases of AML, the positive rate of lymphoid antigen was 58.49% （62/106）. （2）CR ratio and RFS of CD56 ^＋ AML and Ly ≥2 ^＋ AML patients had significant difference when compared with Ly^- AML patients （P 〈 0. 05）. （3）CR ratio and RFS of CD7^ ＋ AML and CD19^ ＋ AML patients had no significant difference when compared with Ly^- AML patients （ P 〉 0. 05 ）. Conclusion CD56 ＋ AML and Ly ≥ 2^＋ AML have bad prognosis.