应重视化疗在肌层浸润性膀胱癌保留膀胱治疗中的作用

Applications of chemotherapy in muscle invasive bladder cancer with bladder preservation

化疗是近年来肌层浸润性膀胱癌重要的辅助治疗手段,对于临床要求保留膀胱的患者意义重大。本文介绍了新辅助化疗和辅助化疗的作用及效果,对经尿道根治性膀胱肿瘤切除术(transurethral resection of bladder tumor,TURBT)联合化疗以及膀胱部分切除术联合化疗的方法及疗效进行综述,同时对一些特殊患者例如肾脏移植患者及透析患者的化疗进行了介绍;最后对当前化疗中存在的药物敏感性问题加以阐述,并对今后化疗在肌层浸润性膀胱癌保留膀胱的发展前景进行了展望。

Chemotherapy has been developing to be an important adjuvant treatment methods in treatment of muscle invasive bladder cancer in recent years. Such method is meaningful for patients who want to preserve the bladder. The author summarized the role and effect of neoadjuvant chemotherapy and adjuvant chemotherapy. This article reviews the methods and effect of radical transurethral resection of bladder tumor with chemotherapy and partial cystectomy with chemotherapy. Data of several special patients including patients with renal transplantation and dialysis patients undergoing chemotherapy are presented. The problems existing in current drug sensitivity of chemotherapy are discussed finally. The future of chemotherapy in muscle invasive bladder cancer with bladder preservation is predicted.