聚(乳酸-羟基乙酸)共聚物涂层的释药性能

Drug Release Properties of Poly(lactic-co-glycolic acid) Coatings

以乙酸乙酯为溶剂,配制聚(乳酸-羟基乙酸)共聚物(PLGA)雷帕霉素溶液,利用滴涂法在316L不锈钢表面制备PLGA载药涂层。于37℃磷酸盐缓冲液(PBS)中进行体外动态药物释放,并用紫外-可见分光光度计测定药物释放量。结果表明:PLGA涂层中PLGA分子量越小,羟基乙酸(GA)含量越高,药物释放越快;药物释放量与滴涂量呈线性关系,药物释放率与滴涂量的倒数呈线性关系;涂层中药物含量增加,其释放量也随之增加,而药物释放率先增加后降低。

Poly（lactic-co-glycolic acid） （PLGA） rapamycin （Rap） solutions were prepared using ethyl acetate as solvent, and then PLGA coatings loading Rap were prepared through drop-coating method on the surface of 316L stainless in a shaking bath. The Rap release kinetics of PLGA coatings was studied in phosphate buffer solution （PBS） at 37 ℃ while oscillating. The mass of Rap released was measured by ultraviolet and visible spectrophotometer. Results showed that a smaller molecular weight of PLGA and a higher ratio of glycolic acid （GA） in PLGA led to a higher release rate of Rap from the coating. Rap release mass depended linearly on the volume of drop-coating solution, and the relationship between Rap release ratio and reciprocal of the volume of drop-coating solution also showed linear. With the increasing of Rap loading, Rap release mass increased non-linearly, however Rap release ratio initially increased and then decreased.