小儿复方四维亚铁散治疗小儿厌食症的临床研究

Clinical study of Pediatric Compound Four Vitamins and Ferrous Fumarate Powder in treatment of infantile and children's anorexia

目的 探讨小儿复方四维亚铁散对小儿厌食症的治疗效果及其对患儿血清淀粉酶（AMS）、胃泌素（Gas）水平的影响。方法 选取2012年1月-2013年12月在遂宁市中心医院门诊就诊的84例厌食症患儿为研究对象，根据随机数字表将患儿分为对照组和治疗组，每组各42例。对照组患儿口服葡萄糖酸锌口服液，6个月～1岁2.5 mL/次，1～3岁5 mL/次，3～5岁10 mL/次，5～8岁15 mL/次，3次/d。治疗组口服小儿复方四维亚铁散，〈1岁0.5包/次，1～3岁1包/次，4～6岁1.5包/次，7～12岁2包/次，1～2次/d。两组患者2周为1个疗程，均持续服用2个疗程。治疗后，观察两组患儿的疗效，并比较两组治疗前后体质量、体质量身高指数（BMI）、血红蛋白（Hb）、血清Zn、AMS、Gas水平的变化。结果 治疗组和对照组的总有效率分别为95.24%、76.19%，两组比较差异有统计学意义（P〈0.05）。治疗后，两组患儿体质量、BMI、Hb、Zn、AMS、Gas水平均高于治疗前，且治疗组显著高于对照组，差异有统计学意义（P〈0.05）。结论 小儿复方四维亚铁散对小儿厌食症有较好的临床疗效，能有效增加患儿体质量和BMI，改善患儿贫血症状，值得临床推广应用。

Objective To investigate the effect of Pediatric Compound Four Vitamins and Ferrous Fumarate Powder in the treatment of infantile and children＇s anorexia and its effects on serum amylase （AMS） and gastrin （Gas） levels. Methods Children with anorexia （84 cases） who came to Center Hospital of Suining City from January 2012 to December 2013 were chosen for the study. They were divided into control and treatment groups based on a random number table, and there were 42 cases in each group. The patients in the control group were po administered with Zinc Gluconate Oral Solution, 6 months to 1-year old children by 2.5 mL/time, 1--3-year old by 5 mL/time, 3--5-year old by 10 mL/time, 5--8-year old by 15 mL/time, 3 times daily. The patients in the treatment group were po administered with Pediatric Compound Four Vitamins and Ferrous Fumarate Powder, 〈 1 year by 0.5 packet/time, 1--3-year old by 1 packet/time, 4-6-year old by 1.5 packets/time, 7-- 2-year old by 2 packets/time, one or two times daily. Two weeks were as one course, and two groups were treated for 2 courses. The treatment effects were observed in the two groups after the treatment, and at the same time, the weight, body mass height index （BMI）, lib, Zn, AMS, and Gas levels in serum of children were compared between the two groups before and after the treatment. Results The total effective rates of children in the treatment and control groups were 95.24% and 76.19% with the significant difference （P 〈 0.05）. After the treatment, weight, BMI, Hb, Zn, AMS, Gas levels in the two groups were higher than those before the treatment, and those in the treatment group was significantly higher than the control group, and the differences between the two groups were statistically significant （P 〈 0.05）. Conclusion Pediatric Compound Four Vitamins and Ferrous Powder has good clinical efficacy in the treatment ofinfautile and children＇s anorexia, and it can increase body weight and BMI effectively, while improve the symptoms of anemia in children, which is worthy of clinical application.