口吸鼻呼丙酸倍氯米松粉雾剂的方式治疗青中年中度支气管哮喘合并过敏性鼻炎

TREATMENT OF MODERATE BRONCHIAL ASTHMA COMBINED WITH ALLERGIC RHINITIS OF YOUNG AND MIDDLE AGED PEOPLE BY INHALING AND NASAL SPRAY BECLOMETHASONE

目的探讨丙酸倍氯米松粉雾剂治疗中青年中度支气管哮喘合并过敏性鼻炎的疗效,寻求一种高效、经济、安全、可靠的给药途径和方法。方法 84例随机分为:治疗组41例经口吸再经鼻呼丙酸倍氯米松粉雾剂每次200μg,3次/d,富马酮替芬1mg,2次/d;对照组43例,经口吸再经口呼丙酸倍氯米松气雾剂250mg,3次/d,富马酮替芬1mg,2次/d,二组按需给予沙丁胺醇2.4mg,每日不过3次。疗程均为12周。结果治疗后二组在白天症状,夜间症状,哮喘和鼻炎的控制,FEV1、FEV1占预计值和PEF值比较治疗组改善显著优于对照组(经秩和检验P>0.01)。结论经口吸再经鼻呼丙酸倍氯米松粉雾剂的方式治疗青中年中度支气管哮喘合并过敏性鼻炎可取得较好的疗效,是一种高效、经济、安全、可靠的给药途径和方法。

Objective To explore the treatment effect of moderate bronchial asthma combined with allergic rhinitis of young and middleaged people by inhaling and nasal spray beelomethasone and to look for a highly efficient, safe, economic and reliable drug delivery route and methods. Methods A sample of 84 cases was randomly divided into the treatment group and the control group. 41 cases in the treatment group were treated with inhaling the beclomethasone through mouth and then breathing out the beclomethasone by nasal, 200ug at a time, 3 times/d, fumaric acid ketotifen ling, 2 times/d. 43 cases in the control group were treated with inhaling and then breathing out the beclomethasone by mouth, 250mg at a time and 3 times/d, fumaric acid ketotifen ling, 2 times/d. 2.4 nag salbutamol was given to the two groups when needed per day, up to three times a day were allowed, and a course of 12 weeks. Results After treatment, the symptom during the day and the night and the eontrol of asthrna and rhinitis, the prediction value of FEV1 and FEV1 and PEF value in the treatment group were better than that in the control group （P 〉 0.01, by rank and inspection）. Conclusion The treatment of moderate bronchial asthma combined with allergic rhinitis of young and middle - aged people by inhaling beclomethasone by mouth and breathing out beelomethasone by nose is a kind of high efficient, safe, economic and reliable drug deliver route and methods.