连续肾脏替代疗法治疗对挤压综合征致多器官功能障碍患者C-反应蛋白以及前白蛋白水平的影响

THE INFLUENCE OF CRRT TREATMENT FOR MULTIPLE ORGAN DYSFUNCTION CAUSED BY CRUSH SYNDROME ON THE LEVELS OF C-REACTIVE PROTEIN AND PRE ALBUMIN

目的观察连续肾脏替代疗法(CRRT)治疗对挤压综合征致多器官功能障碍患者的C-反应蛋白以及前白蛋白水平的影响。方法选取2010年2月—2013年2月住院治疗的挤压综合征导致的多器官功能障碍患者50例作为研究对象。随机分为观察组和对照组,观察组患者采取CRRT治疗,对照组患者采取常规保守治疗。结果观察组的有效率95.8%明显高于对照组80.8%,差异具有统计学意义(P<0.05)。二组患者治疗前后的CRP、PA水平以及APACHEⅡ评分比较差异具有统计学意义(P<0.05),治疗后的差异具有统计学意义(P<0.05),治疗前的差异无统计学意义(P>0.05)。结论 CRRT治疗挤压综合征致多器官功能障碍疗效显著,有效调节CRP和PA水平,具有一定的临床价值。

Objective To investigate the influences of CRRT treatment for multiple organ dysfunction caused by crush syndrome on the C- reactive protein level and pre albumin level. Methods Fifty patients with multiple organ dysfunctions received treatment in Hanzhong Central hospital from February 2010 to February 2013 were selected as the subjects, which were randomly divided into experimental group and control group. While the experimental group was given CRRT treatment, the patients in the control group adopted conventional conservative treatment. Results The effective rate in experimental group was 95.8%, higher than that of control group 80.8%, the difference was statistically significant （P〈0.05）. CRP, PA level and APACH Ⅱ score registered statistically significant difference before and after treatment （P〈0.05）, the difference was statistically significant after treatment （P〈0.05）, while there was no significant difference before treatment （P〉0. 05）. Conclusion CRRT treatment for multiple organ dysfunctions caused by crush syndrome produce significantly curative effect, can effectively regulate the level of CRP and PA, and has some clinical value.