婴幼儿腹泻时血清锌含量测定的意义

The Clinical Significance of Serum Zinc Content Variation in Infants with Diarrhea

目的：探讨婴幼儿腹泻时血清锌含量变化，改善腹泻患儿锌营养状况，提高婴幼儿腹泻病防治水平。方法：2010年1月～2012年10月诊治的1个月至3岁腹泻患儿95例和同期门诊健康体检的271名婴幼儿为研究对象，化学发光检测法测定血锌含量，SPSS16．0统计学软件进行统计学分析。结果：健康对照组、急性腹泻组和迁延性腹泻组患儿血清锌含量（x^-±s）分别为：19．64±2．82μmol／L。13．15±3．18μmol／L。14．11±3．06μmol／L，锌缺乏发生率分别0，12．98％，5．56％。急性腹泻组及迁延性腹泻组患儿血清锌含量显著降低，锌缺乏发生率明显升高。结论：腹泻婴幼儿血清锌舍量显著降低，锌缺乏发生率明显升高。婴幼儿腹泻可常规检测体内锌值，指导临床合理补锌。

Objective：To investigate the content variation of serum zinc and the incidence of zinc deficiency in infants with diarrhea, we try to improve their zinc status and the prevention level of diarrhea. Methods： The eases of 95 infants diagnosed with diarrhea in department of pediatrics, the first affiliated hospital of fujian medical university from January 2010 to October 2012, and 271 infants with health physical examination in outpatient service in the same period, the age of all infants is not more than 3 years old. The serum was seperated by centrifugation, using colorimetric method to measure serum zinc levels. All data were statistically analysed by SPSS version13.0. Results：The level of serum zinc （ x ± s, μmol/L） was （ 19.64 ± 2.82 ）, （ 13.51 ± 3.18）, （ 14.11 ± 3.06） in control group, acute diarrhea, persistent diarrhea, and the incidence of zinc deficiency was 0, 12.98 96, 5.56 96. The level of serum zinc in acute diarrhea, persistent diarrhea was significantly less than control group, the incidence of zinc deficiency was significantly more than control group. Conclusions： Compared with control group, the level of serum zinc of infants with diarrhea was significantly less, the incidence of zinc deficiency was significantly more. We can measure serum zinc routinely in children with diarrhea, guiding the reasonable zinc supplementation, and improving their zinc status and the prevention level of diarrhea. Regular blood zinc content determination can be undertaken in infant diarrhea, which can help to improve the zinc nutritional status in children with diarrhea and raise the level of prevention and control in infant diarrhea.