不同促渗剂对秦皮甲素乳膏透皮吸收的影响

Effects of different types of penetration enhancers on percutaneous absorption of aesculin cream

目的:制备秦皮甲素乳膏,并通过动物离体透皮吸收实验,选择秦皮甲素乳膏中最佳透皮吸收促渗剂。方法:采用透皮扩散装置,以生理盐水为接收介质,以小鼠离体腹部皮肤为透皮屏障,优选出最佳的透皮吸收促渗剂。结果:最优的透皮吸收促渗剂为5%冰片,最佳处方的动力学方程为:y=0.668x+1.825 6,r=0.999 1。结论:5%的冰片作为秦皮甲素乳膏的透皮吸收促渗剂具有良好的效果。

Objective： To prepare aesculin cream and to study the effect of four types of penetration enhancers on percutaneous absorption of aesculin across mice skin. Methods： Diffusion cell method was applied to investigate transdermal absorption behavior of the aescuhn cream using isolated mouse skin as barrier to determine the best penetration enhancer. Results： Optimal penetration enhancer was the 5% borneo1. The dynamic equation of the best formulation was y=0.668x＋1.825 6, r=0.999 1. Conclusion： 5% borneol as aesculin cream penetration enhancer is the best.