不同水解程度乳清蛋白配方奶辅助治疗婴儿湿疹疗效观察

Role of whey protein hydrolyzed formula as an adjunctive therapy for treating patients with infantile eczema

目的探讨深度水解乳清蛋白配方奶及适度水解乳清蛋白配方奶作为婴儿湿疹辅助治疗措施的临床价值。方法将59例人工喂养患有婴儿湿疹的足月儿按喂养配方不同分为深度水解乳清蛋白配方组（eHF组，n=18）、适度水解乳清蛋白配方组（pHF组，n=22）及普通牛奶配方组（CMF组，n=19），在外用药物治疗相同的情况下，利用特应性皮炎积分指数观察治疗的有效率、缓解率等。结果治疗2周后eHF组治疗有效率38．9％及缓解率50．0％，与CMF组的5．3％及31．6％相比差异有统计学意义（χ^2=12．225，P=0．002）；pHF组治疗有效率9．1％及缓解率40．9％，与CMF组相比差异无统计学意义（χ^2=0．761，P=0．683）。治疗8周后，eHF组治疗有效率55．6％及缓解率38．9％，与CMF组的15．8％及47．4％相比差异有统计学意义（r=8．498，P=0．014）；pHF组治疗有效率31．8％及缓解率59．1％有高于CMF组的趋势，但差异无统计学意义（χ^2=4．912，P=0．086）。治疗前（F=0．773，P=0．466）、后（F=1．313，P=0．277）小儿生长发育指标各组间差异无统计学意义。结论深度水解乳清蛋白配方及适度水解乳清蛋白配方奶均可辅助治疗婴儿湿疹，但深度水解配方治疗显效较快。

Objective Tn study the clinical value of extensively whey protein hydrolyzed formula and partially whey protein hydrolyzed formula as an adjunctive therapy in treating infantile eczema. Methods Totally 59 bottle-feeding babies with infantile eczema were divided into three groups depending on different formula feeding： extensively hydrolyzed formula feeding group （eHF group, n = 18 ）, partially hydrolyzed formula feeding group （ pHF group, n = 22 ）, and conventional cow＇s milk formula feeding group （ CMF group, n = 19 ）. Meanwhile, all patients received the same drug treatment. The effective rate and remission rate were evaluated using the SCORing Atopic Dermatitis （SCORAD） index. Results After 2 weeks of treatment, the effective rate was 38.9% and the remission rate was 50. 0% in the eHF group, which were significantly different from those in the CMF group （5.3% and 31.6% ） （χ^2 = 12. 225, P =0. 002）. The effective rate was 9. 1% and the remission rate was 40. 9% in the pHF group, showing no significant difference when compared with the CMF group （X2 =0. 761, P =0. 683）. After 8 weeks of treatment, the effective rate was 55.6% and the remission rate was 38.9% in the eHF group, comparing to 15.8% and 47.4% in the CMF group, the difference was statistically significant （χ^2 = 8. 498, P = 0. 014）. The effective rate was 31.8% and the remission rate was 59. 1% in the pHF group, a trend towards higher than that of the CMF group, but the difference was not statistically significant （χ^2 = 4. 912, P = 0. 086）. Before （ F = 0. 773, P = 0. 466） and after （ F = 1. 313, P =0. 277 ） the treatment, the growth and development data in different groups showed no significance differences. Conclusion Both the extensively and partially whey protein hydrolyzed formula play an adjunctive role in treating infantile eczema, although the treatment effectiveness of the extensively hydrolyzed formula appears earlier than that of the partially hydrolyzed formula.