针灸对妇科肿瘤病人化疗后癌性疲劳影响的研究

Effect of Acupuncture Therapy on Cancer- related Fatigue of Patients with Gynecological Malignant Tumor after Chemotherapy

目的:采用简易疲劳评估量表(BFI)及中医症候临床症状评分量表分别评价传统针灸治疗对妇科肿瘤化疗后癌性疲乏的影响。方法:将120例符合标准的妇科肿瘤将行化疗患者随机分为实验组即进行针灸治疗组,药物组即口服西洋参治疗组,空白组不接受以上治疗,每组40例,3组患者均按照既定化疗方案施行化疗。实验组于化疗第1天开始针灸治疗,每日1次,1周3次,共治疗3周。药物组开始口服西洋参,2000 mg/天,每日3次连用3周。空白组未给予其他干预措施。分别在化疗前、化疗第3天(化疗后)和化疗3周(治疗后)分别采用BFI及中医症候评价对3组患者进行评价,比较评价结果。结果:化疗前3组患者的综合疲乏程度相当,BFI评估及中医症候评分无显著差异(P>0.05);化疗后3组患者的上述评分均显著升高(P<0.01);治疗后实验组患者的上述评分均显著降低(P<0.01)。但BFI评分、中医症候评分及改善率,实验组与药物组相比没有显著差异(P>0.05)。结论:针灸治疗可以明显改善癌性疲劳,虽与口服西洋参比较没有显著优势,但其有效性使针灸有望成为癌性疲乏的一种可靠的辅助治疗手段。

Objective：We used brief fatigue inventory （ BFI ） and symptom of Chinese medicine scores to as-sess the effectiveness of acupuncture for cancer -related fatigue （ CRF） in patients with gynecological malignant carcinoma.Methods：By perspective, clinical research randomized method , based on 120 patients with cancer-related fatigue in the gynecology of Harbin Medical University Cancer Hospital .The patients were ran-domly divided into normal trial group （ 40 cases ） , medicine group （ 40 cases ） and control group （ 40 cases ） . The patients in the two intervention trial groups were treated by acupucnture therapy , oral american ginseng re-spectively, from the first day of chemotherapy .Acupuncture sessions lasted 20 miniutes, and 3 times weekly, while patients of medicine group with 2000mg/d,3 times daily, totally 3 weeks.The control group had no treat-ment.The outcome indexes were measured in the first , the third day of chemotherapy and after three weeks . SPSS13.0 was used for data analysis .Results：Before therapy , the differentiations of cancer -related fatigue scores of three groups were not evident in statistics （ P〉0 .05 ） .After chemotherapy , the scores of the three groups became higher than before （P〈0.01）.The scores of the two intervention groups were much lower than that of the control group and this was considered to have a statistical significance （ P〈0 .01 ） .The scores of BFI and response rate of symptoms of Chinese medicine of symptoms of acupuncture group showed no significant improvement compared with medicine group （ P〉0.05）.Conclusion：The acupuncture therapy can treat the cancer-related fatigue and improve the quality of life for patients with gynecological malignant tumor after chemotherapy treatment.The use of acupuncture should also be tested to be the most effective and convenient method for CRF .