摘要
目的研究Oxford 40(OX40)和OX40配体(OX40L)在胃癌及癌前病变中的表达及其意义。方法收集复旦大学附属中山医院内镜中心胃部内镜黏膜下剥离术标本43例,分为慢性非萎缩性胃炎、胃黏膜上皮轻中度不典型增生、胃黏膜上皮重度不典型增生或胃癌3组,采用EnVision二步法检测各种病变中OX40、OX40L的实质细胞表达,并分析其与病变临床病理特征的关系。结果 OX40的实质细胞表达在胃黏膜上皮重度不典型增生中较胃癌、胃黏膜上皮轻中度不典型增生、慢性非萎缩性胃炎中高(P<0.05)。OX40L的实质细胞表达在胃黏膜上皮轻中度不典型增生、胃黏膜上皮重度不典型增生或胃癌中较慢性非萎缩性胃炎中高(P<0.05)。结论 OX40、OX40L参与机体抗不典型增生和抗肿瘤免疫反应,其表达的变化可能与胃癌的发生、发展有关。
Objective To study the expression of Oxford 40（OX40）and Oxford 40ligand（OX40L）in gastric cancer and gastric precancerous lesions and its significance.Methods The gastric endoscopic submucosal dissection（ESD）paraffin specimens of 43patients were collected from the department of endoscopy in Zhongshan Hospital.They were divided into three groups,including chronic non-atrophic gastritis,gastric mild-moderate dysplasia,gastric severe dysplasia or cancer.Immunohistochemistry（IHC）EnVision method was applied to examine the expression of OX40and OX40Lin tissues with different pathological types and evaluate the relationship with clinicopathological features of different lesions.Results The level of OX40expression in parenchymal cells in gastric severe dysplasia tissues was higher than that in chronic non-atrophic gastritis,gastric mild-moderate dysplasia and cancer tissues（P〈0.05）.The level of OX40Lexpression in parenchymal cells in gastric mild-moderate dysplasia,severe dysplasia or cancer tissues were higher than that in chronic non-atrophic gastritis tissues（P〈0.05）.Conclusion OX40and OX40Lare involved in the anti-dysplasia and anti-tumor immune responses in human body.Their expression changes and may be involved in the occurrence and development of gastric cancer.
出处
《福建医药杂志》
CAS
2014年第3期78-82,共5页
Fujian Medical Journal
