AS患者血浆MCP-1、bFGF水平变化与疾病进展关系的研究被引量：1

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摘要目的观察动脉粥样硬化(atherosclerosis,AS)患者血浆单核细胞趋化因子(monocyte chemoattractic prptein-1,MCP-1)、碱性成纤维生长因子(basic fibroblast growth factor,bFGF)水平与病变进展的相关分析。方法分别收集50例AS患者作为实验组、健康体检者32例作为对照组。采用酶联免疫吸附法检测血浆MCP-1、bFGF水平,同时收集患者临床病理参数,分析血浆MCP-1、bFGF水平与动脉硬化进展的内在联系。结果 AS组MCP-1水平明显高于对照组,差异有统计学意义(P<0.01),且血浆MCP-1水平与患者冠脉病变支数、冠脉病变程度、E/A比值、射血分数间呈正相关(r值分别为0.3541、0.5501、0.6237和0.8564,P<0.05);AS组血浆bFGF水平明显高于对照组,差异有统计学意义(P<0.01),且血浆bFGF水平与冠脉病变程度、左室射血分数间呈正相关(r值分别为0.6359和0.8751,P<0.01);血浆MCP-1与bFGF水平之间呈正相关(r=0.4702,P<0.01)。结论 MCP-1、bFGF是促进AS进展的关键因素,动态检测其变化可以评估疗效及预后。

作者郝建萍马成龙张凡

机构地区河北省康保县医院心内科河北北方学院附属第一医院病理科

出处《河北医药》 CAS 2014年第13期2014-2016,共3页 Hebei Medical Journal

关键词单核细胞趋化因子碱性成纤维生长因子动脉粥样硬化

分类号 R543 [医药卫生—心血管疾病]

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