电压门控钠离子通道与疼痛症

Voltage-gated Sodium Channels in Pain

疼痛是一种常见的疾病和临床症状,有时会严重影响患者的生活质量,因此,疼痛的研究、治疗具有重要的实际意义。电压门控钠离子通道在神经元动作电位的起始和传导中起着关键作用,尤其是亚型Nav1.3、Nav1.7、Nav1.8和Nav1.9,它们广泛存在于背根神经节中,参与了疼痛的形成。其中,Nav1.7的基因突变会导致多种遗传性疾病。因此,这些亚型是潜在的、理想的疼痛治疗靶点。主要对电压门控钠离子通道与疼痛有关的最新研究进展进行了综述。

An individual＇s quality of life can be severely affected by pain, a common disease and clinical symptom. Vohage-gated sodium channels are proved to play an essential role in the initiation and propagation of action potentials in neurons. It＇s reported that the subtypes Nav13, Nav1.7, Nav1.8 and Nav1.9 locating in the dorsal root ganglia cells participate in the formation of pain. And mutations in the Nav1.7 have been described to cause several inherited pain diseases. Therefore, these subtypes are potential targets for novel pain therapeutics. Here, the contribution of voltage-gated sodium channels to pain is discussed.