翼状胬肉与泪膜稳定性的关系研究

Correlation between pterygium and tear film stability

目的研究原发性翼状胬肉发生与泪膜稳定性间的关系。方法对在2012—10—2013—06就诊于我院眼科门诊的单眼原发性翼状胬肉患者63例（其中静止期28例，进行期35例）的临床资料进行回顾性分析。以翼状胬肉眼为病例组，对侧健眼为正常对照组，检查泪膜破裂时间（break—uptime，BUT）并进行比较。结果静止期翼状胬肉病例组BUT值为（9．23±0．44）s，相应正常对照组为（9．49±0．46）s，两组问差异无统计学意义（P〉0．05）；进行期翼状胬肉病例组BUT值为（7．80±0．46）s，相应正常对照组为（9．39±0．45）s，两组间差异有统计学意义（P〈0．05）；进行期翼状胬肉组BUT值较静止期翼状胬肉组BUT值缩短，两组间差异有统计学意义（P〈0．05）。结论静止期原发性翼状胬肉对泪膜稳定性无影响，而进行期翼状胬肉可导致泪膜稳定性的下降，表现为泪膜破裂时间的缩短。

Objective To explore the relationship between primary pterygium and tear film stability. Methods The clinical data of 63 patients with primary pterygium in a single eye were recruited from the ophthalmic outpatient clinic from October 2012 to June 2013. There were 28 eyes in the clinical quiescent stage and 35 eyes in the progressive stage. Each patient had a pterygium eye （case group） and a normal control eye （ control group）. Break-up time （BUT） between pterygium eyes and normal eyes were examined and com- pared. Results The tear film BUT showed no significant difference between case group in the quiescent stage and normal control group [ （ 9.23 ±0.44 ） s vs （ 9.49 ±0. 46 ） s, P 〉 0. 05 ]. The tear film BUT was significantly lower in the progressive stage in case group than in normal control group [ （7.80 ± 0.46 ） s vs （9.39 ± 0.45 ） s ,P 〈 0.05 ]. Compared with the clinical quiescent stage subjects, the tear film BUT in the progressive stage subjects was significantly reduced （P 〈 0.05）. Conclusion Pterygium in the quiescent stage has no effect on the stability of tear film. But pterygium in the progressive stage could reduce tear film stability.