木犀草素抑制乳腺癌细胞MDA-MB-231中SDF-1α/CXCR4通路的作用

Inhibition Effect of Luteolin on SDF-1α/CXCR4 Signal Pathway in Breast Cancer Cells MDA-MB-231

目的探讨木犀草素对乳腺癌细胞MDA-MB-231中SDF-1α/CXCR4信号通路抑制作用。方法采用不同浓度的木犀草素处理乳腺癌细胞MDA-MB-231,观察乳腺癌细胞MDA-MB-231的细胞增殖、趋化运动及CXCR4蛋白表达。结果木犀草素明显抑制乳腺癌细胞MDA-MB-231增殖,明显抑制乳腺癌细胞MDA-MB-231 CXCR4蛋白表达,并明显抑制SDF-1α/CXCR4对乳腺癌细胞MDA-MB-231的激活。结论木犀草素可抑制乳腺癌细胞MDA-MB-231增殖及SDF-1α/CXCR4介导的乳腺癌细胞的信号激活作用,在预防乳腺癌复发及转移中可能有重要的作用。

Objective To study the inhibition Effect of luteolin on SDF-la/CXCR4 signal pathway in breast cancer cells MDA-MB-231. Methods Different concentrations of luteolin were used to treat breast cancer cells MDA-MB-231, the cell enhancement, chemotactic migration and expression of CXCR4 were observed in breast canc- er cells MDA-MB-231. Results Luteolin inhibited significantly the cell proliferation,the expression of CXCR4 and SDF-la/CXCR4 activation in the breast cancer cells of breast cancer cells MDA-MB-231. Conclusion Luteolin can inhibit the cell proliferation and SDF-la/CXCR4 signal activation of breast cancer cells MDA-MB-231, and may be important in the prevention of recurrence and metastasis of breast cancer.