放疗联合周剂量紫杉醇治疗老年食管癌的临床研究

Effects of Weekly Dose Paclitaxel Combined with Radiotherapy on Elderly Patients with Esophageal Carcinoma

目的探讨放疗联合周剂量紫杉醇治疗老年食管癌的疗效及毒副反应。方法 49例老年食管癌患者随机分为同步放化疗组（24例）和单纯放疗组（25例）,2组放疗均采用常规分割,照射剂量60~66 Gy。同步放化疗组紫杉醇60 mg,每周1次,连续6周。结果同步放化疗组有效率87.5%,高于单纯放疗组的60.0%（P〈0.05）。同步放化疗组Ⅱ、Ⅲ度白细胞减少占54.2%,明显高于单纯放疗组的20.0%（P〈0.05）。结论放疗联合周剂量紫杉醇治疗老年食管癌近期疗效较好,毒副反应相对加重但可耐受。

Objective To evaluate the efficacy and toxicities of weekly dose paclitaxel combined with radiothera- py for elderly patients with esophageal carcinoma. Methods Forty-nine elderly patients with esophageal carcinoma were randomly divided into two groups,24 patients of the concurrent chemotherapy and radiotherapy group received the 60-66 Gy of routine radiotherapy plus weekly dose paclitaxe1,60 mg of paclitaxel was administered once a week for 6 successive weeks starting from the first day of radiotherapy, and 25 patients of the radiotherapy group received the 60-66 Gy of routine radiotherapy. Results The response rate of the concurrent chemotherapy and radiotherapy group was 87.5% ,and was 60.0% in the radiotherapy group（ P 〈 0.05 ）. The occurrence rate of leucopenia with grade Ⅱ or Ⅲ was 54.2% in the concurrent chemotherapy and radiotherapy group,and was 20.0% in the radio- therapy group（ P 〈 0.05 ）. Conclusion Weekly dose paclitaxel combined with radiotherapy is effective for the eld- erly patients with esophageal carcinoma, and the toxicities can be tolerated.