摘要
目的比较盐酸羟考酮缓释片(奥施康定)与曲马多缓释片(奇曼丁)治疗中度癌痛的近期疗效。方法将100例伴有中度癌痛患者随机分为奥施康定组和奇曼丁组,每组50例,分别接受奥施康定和奇曼丁的治疗。结果奥施康定组治疗后第3、7、10天的NRS评分均较奇曼丁组低,且奥施康定组治疗后第3天NRS评分下降幅度较奇曼丁组明显(P<0.05);奥施康定组的CR率和有效率分别为34.0%和100.0%,明显高于奇曼丁组的10.0%和84.0%(P<0.05);2组毒副反应发生率比较差异均无统计学意义(P>0.05)。结论与奇曼丁相比,应用奥施康定治疗中度癌痛患者,能更快更有效缓解疼痛,而未增加毒副反应。
Objective To compare the efficacy and tolerability of oxycodone hydrochloride controlled-release tab-lets (oxycodone) and tramadol hydrochloride sustained-release tablets (tramadol) in the treatment of patients with moderate cancer pain. Methods A total of 100 patients with moderate cancer pain were randomly divided into two groups,50 patients of the oxycodone group was treated with oxycodone, and 50 patients of the tramadol group was treated with tramadol Results The NRS scorce in the oxy- codone group had declined more significantly than the tramadol group, and the decrease was statistically significant in the first three days (P 〈 0.05 ). The CR rate and the response rate in the oxycodone group were significantly better than those of the tramadol group (34.0% vs 10.0% and 100.0% vs 84.0% ) ( P 〈 0.05 ). There was no statistic significant difference in the toxicity incidences be- tween the two groups(P 〉 0.05 ). Conclusion Compared with tramadol, oxycodone is faster and more effective to relieve pain, and don' t increase the toxicities.
出处
《肿瘤基础与临床》
2014年第3期242-244,共3页
journal of basic and clinical oncology
关键词
盐酸羟考酮缓释片
曲马多缓释片
癌痛
oxycodone hydrochloride controlled-release tablets
trarnadol hydrochloride sustained-release tablets
cancer pain