VEGF-C、nm23 H_1在宫颈增生性病变中的表达及临床意义

Expression and clinical significance of VEGF-C and nm23 H_1 in cervical hyperplasia lesions

目的探讨血管内皮生长因子C(VEGF-C)和肿瘤转移抑制基因(nm23 H_1)在宫颈增生性病变发生、发展过程中的表达及其临床意义。方法采用免疫组织化学法检测51例宫颈鳞状细胞癌组织中VEGF-C和nm23 H_1的表达水平,以31例宫颈炎性、修复性增生组织,27例宫颈上皮内瘤变组织做对照,对结果进行分析。结果在宫颈炎性、修复性增生组织,宫颈上皮内瘤变及宫颈鳞状细胞癌组织中,VEGF-C的表达分别为3.2%、40.7%、72.5%,3组间比较有显著性差异(x～2=37.702,P<0.01);nm23 H_1的表达分别为100.0%、59.2%、33.3%,3组间比较有显著性差异(x～2=35.349,P<0.01)。在宫颈鳞癌组织中,VEGF-C和nm23 H_1在伴有淋巴结转移的组织中阳性表达率为87.5%和16.7%;未伴淋巴结转移中阳性表达率为59.3%和48.1%。在宫颈增生性病变组织中,无论有无淋巴结转移,VEGF-C与nm23 H_1阳性表达始终呈负相关(r=-0.532,P<0.05)。结论 VEGF-C和nm23 H_1存在相关性,并在宫颈鳞癌的发生、发展、预后和转移方面发挥着重要作用,其可作为评价宫颈病变、推测预后的重要参考指标。

Objective To explore the expression and clinical significance of VEGF-C and nm^23 H1 in the occurrence and development of cervical hyperplasia lesions .Methods Immunohistochemistry was used to test the expression of VEGF-C and nm^23 H1 in 51 samples of cervical squamous cell carcinoma tissues .The control group included 31 samples of normal cervical , inflammatory or reparative hyperplasia tissues and 27 samples of cervical intraepithelial neoplasia tissues .The results were analyzed .Results In cervical inflammatory and reparative hyperplasia tissues , cervical intraepithelial neoplasia tissues and cervical squamous cell carcinoma tissues , the positive expression rate of VEGF-C was 3.2%, 40.7%and 72.5%, respectively.The difference among them was significant （χ^2 =37.702, P〈0.01）.The expression of nm^23 H1 was 100.0%, 59.2%and 33.3%, respectively, and there was significant difference （χ^2 =35.349, P〈0.01）.The positive expression rate of VEGF-C and nm^23 H1 were 87.5%and 16.7%, respectively in cervical carcinoma tissue with lymph node metastasis, and 59.3% and 48.1%, respectively in cervical carcinoma tissue without lymph node metastasis .VEGF-C expression was negatively correlated with nm 23 H1 in cervical hyperplasia lesions with or without lymph nodes metastasis （r=-0.532,P〈0.05）.Conclusion VEGF-C is correlated with nm^23 H1, and they play an important role in the occurrence , development, prognosis and metastasis of cervical squamous cell carcinoma , which may be important reference indexes for evaluating severity and predicting prognosis of cervical lesions .