安吉县育龄妇女HPV感染及CIN患病情况的调查分析

Survey on HPV infection and cervical intraepithelial neoplasia in childbearing women in Anji County

目的调查安吉县育龄妇女宫颈上皮内瘤变(CIN)的患病情况,以及人乳头瘤病毒(HPV)感染状况,以获得更合理的预防与治疗新方案。方法选取2008年1月至2013年4月在浙江省安吉县人民医院妇产科门诊进行宫颈癌筛查,有性生活的978例育龄妇女为研究对象,根据液基细胞学检查及HPV检测结果,将其分为HPV阳性组和阴性组,分析CIN病变程度及与HPV感染的状况。结果①HPV感染率14.5%,CIN1患病率16.9%,CIN2/3患病率3.6%;②HPV阳性人群中CIN1患病率与HPV阴性组的CIN1患病率差异显著(x～2=211.8,P<0.01),HPV阳性组CIN1患病率(54.9%)显著高于HPV阴性组的(9.7%);HPV阳性人群中CIN2/3患病率与HPV阴性组的CIN2/3患病率有显著性差异(x～2=166.6,P<0.01),HPV阳性组CIN2/3患病率为22.5%,显著高于HPV阴性组(0.5%);③CIN2/3组的HPV检测阳性率(88.9%)显著高于CIN1(50.9%)(x～2=17.5,P<0.01)。结论安吉市女性的CIN患病率与HPV感染率较高,HPV感染率越高,提示CIN病变越严重。

Objective To investigate the prevalence of cervical intraepithelial neoplasia （ CIN ） and humanpapilloma virus （ HPV ） infection among childbearing women in Anji County , so as to explore more reasonable prevention and new treatment scheme .Methods Study subjects included 978 sexually active childbearing women taking screening of cervical cancer in outpatient clinic of gynecology and obstetrics in People’s Hospital of Anji County during the period of January 2008 to April 2013.They were divided into HPV positive group and HPV negative group according to liquid -based cytologic test and HPV test .Prevalence of CIN and HPV infection were analyzed . Results The infection rate of HPV was 14.5%, the prevalence rate of CIN1 was 16.9%, and the prevalence rate of CIN2/3 was 3.6%, respectively.There was significant difference in the prevalence rate of CIN 1 between HPV positive group （54.9%） and HPV negative group （9.7%） （χ^2 =211.8,P〈0.01）, and the prevalence rate of CIN2/3 in HPV positive group （22.5%） was significantly higher than that in HPV negative group （0.5%） （χ^2 =166.6,P〈0.01）.The positive rate of HPV in CIN2/3 group （88.9%） was significantly higher than that in CIN1 group （50.9%） （χ^2 =17.5,P〈0.01）.Conclusion The prevalence rate of CIN and infection rate of HPV are relatively high in women in Anji County .Higher infection rate of HPV indicates more severe CIN .