N-乙酰半胱氨酸泡腾片治疗尘肺的疗效观察

Efficacy of N-acetylcysteine effervescent tablets in treament of patients with pneumoconiosis

目的探讨N-乙酰半胱氨酸(NAC)泡腾片对尘肺患者肺功能及血气分析的影响。方法选取69例Ⅰ、Ⅱ期尘肺患者,分为NAC治疗组、矽肺宁组与空白组,口服药物治疗1年,分析各组肺功能(VC、FEV1%、TLC、DLco)、动脉血气分析,观察NAC治疗尘肺的效果。结果三组治疗前后肺功能(VC、FEV1%、TLC)及血气分析结果显示差异无统计学意义,矽肺宁组及空白组治疗前后DLco比较差异有统计学意义(P<0.05)。NAC治疗组治疗前后DLco差异无统计学意义(P>0.05)。三组治疗前后肺功能(VC、FEV1%、TLC)及血气分析的差值两两比较,差异均无统计学意义(P>0.05)。结论 NAC能抑制肺纤维化进程,改善尘肺患者肺功能及低氧血症,并改善患者的生存状态,缓解呼吸困难等症状。

Objective To explore the effects of N-acetylcysteineon （NAC） on lung function and blood gas analysis in patients with pneumoconiosis. Methods Sixty-nine patients with stage I and n pneumoconiosis were divided into NAC treated group, Xifeining treated group, control group and blank control group. Oral medication for one year, the patients＇s lung function indexes such as vital capacity （VC）, forced expiratory volume in one second （FEV1%）, total lung capacity,TLC）, diffusion capacity for carbon monoxide of the lung （DLco） ,and arterial blood gas analysis were comparatvely analyzed. Observed the efficacy of NAC in treatment of pneumoconiosis. Results Before and after the treatment, pulmonary function （VC, FEV1 %, and TLC） and blood gas analysis results in three groups showed no statistical difference. DLco levels in Xifeining group and blank control group, compared before treatment to after treatment in each group, there were statistically significant differences （ P 〈0.05）, DLco in NAC treatment group, compared before treatment to after treatment, there was no statistical difference （ P〉0.05）. The difference pairwise comparison of lung function （VC and FEV1%, TLC） and blood gas analysis among three groups was done, there were no statistical differences （ P 〉0.05）. Conclusion NAC can inhibit process of pulmonary fibrosis, improve lung function in patients with pneumoconiosis, ameliorate hypoxemia, improve the patients life quality, and ease breathing difficulties and other symptoms.