维汉两族慢性心力衰竭流行病学对比研究(英文)

Comparative study of chronic heart failure epidemiology between Uighur and Han nationality patients

目的：调查维吾尔族和汉族慢性心力衰竭（CHF）患者的病因分布与预后情况，为 CHF的防治提供依据。方法：收集2011年8月-2012年8月喀什地区第二人民医院心内科收治的维吾尔族280例 CHF患者和上海第九人民医院心内科收治的汉族266例CHF患者的资料，随访6个月，对比不同民族CHF患者的发病年龄、性别、原发病、诱因、NYHA心功能分级、合并症、治疗转归等情况。结果：维族心衰患者的平均年龄（59.5±14.7）岁， P＜0.05，显著低于汉族的（76.2±11.4）岁，P＜0.05；维族中青年占61.4％（172/280），显著高于汉族中青年的18.4％（49/266），P＜0.01。冠心病为心衰的主要原因，占维族心衰患者的52.2％（147/280），显著低于汉族的67.3％（179/266），P＜0.001；维族心衰患者中风湿性心脏病比例明显高于汉族（10.0％比5.3％，P＜0.05）。亚组分析显示，维族冠心病合并糖尿病者比汉族多见（40.1％比29.1％，P＜0.05）；心衰的主要诱因为感染，其发生率维族显著高于汉族（60.7％比40.6％，P＜0.001）。与汉族患者比较，半年内的心衰再入院率（18％比24.6％，P＜0.05），心衰死亡率（6.0％比8.2％）维族无显著差异，P 均＞0.05。结论：与汉族相比，维族心衰发病年龄显著较低，中青年心衰患者比例明显较高；冠心病比例维族显著低于汉族，而风湿性心脏病引起心衰的比例显著高于汉族；维族感染发生率显著高于汉族人群。

Objective：To investigate chronic heart failure （CHF）cause distribution and prognosis in Uighur and Han nationality CHF patients in order to provide evidence for prevention and treatment of CHF.Methods：The data of 280 Uighur nationality CHF inpatients of department of cardiology in Kashi Area Second People′s Hospital,and 266 Han nationality CHF inpatients of department of cardiology in Shanghai Ninth People＇s Hospital from Aug 2011 to Aug 2012 were collected;These patients were followed up six months.The onset age,gender,primary diseases,exciting cause,NYHA cardiac function class,complications and therapeutic outcome etc.were compared between CHF patients of two nationalities.Results：Mean age of Uighur nationality was （59.5±14.7）years and significant lower than that of Han nationality （76.2±11.4）years,P〈0.05;Percentage of young and middle-aged patients in Uighur nationality was 61.4% （172/280 cases）was higher than that of Han nationality 18.4% （49/266 cases）,P〈0.01.Coronary heart disease （CHD）was the main cause of CHF,it occupied 52.2% （147/280）in Uighur nationality CHF patients and was significant lower than that of 67.3% （179/266）in Han nationality （P〈0.001）;percentage of rheumatic heart disease in Uighur nationality CHF patients was significantly higher than that of Han nationality CHF patients （10.0% vs.5.3%,P〈0.05）.Subgroup analysis indicated that CHD complicated diabetes mellitus in Uighur nationality patients was significantly more than that in Han nationality patients （40.1% vs. 29.1%,P〈0.05）.The main exciting cause of CHF was infection,its incidence rate in Uighur nationality was significantly higher than that of Han nationality （60.7% vs.40.6%）,P〈0.001.Compared with Han nationality patients,there was no significant difference in rehospitalization rate caused by heart failure （HF）within six months （18% vs.24.6%）and mortality （6.0% vs.8.2%）in Uighur patients,P＆gt;0.05 both.Conclusion：Compared with Han nationality,the onset age is significant lower,percentage of young and middle-aged HF is significant higher in Uighur nationality;CHD percentage of Uighur nationality is lower than that of Han nationality,but percentage of rheumatic heart disease in Uighur nationality is significant higher than that of Han nationality;incidence of infection in Uighur nationality is significant higher than that of Han nationality.