血清尿酸含量及脉搏波传导速度与冠心病的关系

Relationship study among serum uric acid concentration,pulse wave velocity and coronary heart disease

目的：研究血清尿酸（SUA）水平及肱踝脉搏波速度（baPWV）与冠脉病变严重程度的关系。方法：选择我院心血管内科2011年1月至2012年7月住院的121例患者，根据冠脉造影结果分为冠心病组（59例）和正常对照组（62例），再根据冠脉病变支数冠心病组分为单支（30例）、双支（14例）、多支病变组（15例），比较各组SUA及 baPWV，并分析其与冠脉病变程度的关系。结果：SUA浓度随着冠脉病变血管支数的增加而逐渐升高，正常、单支、双支、多支病变组分别为（349.26±96.58）μmol/L、（400.37±70.96）μmol/L、（517.57±85.26）μmol/L、（602.60±77.03）μmol/L （P＜0.05或＜0.01）；baPWV亦随着冠脉病变血管支数的增加而逐渐升高，与正常对照组比较，单支组、双支组和多支组baPWV显著升高[（1499.04±193.82）cm/s比（1885.32±319.73） cm/s、（2036.00±406.40）cm/s、（2171.03±348.53）cm/s]，且双支病变组显著高于单支病变组（P＜0.05-＜0.01）。Logistic回归分析显示，SUA、baPWV是冠心病患病的独立危险因素（OR＝13.011，14.008，P＝0.000）结论：血尿酸水平及脉搏波速度对预测冠心病及其严重程度有重要价值。

Objective：To study the relationship among serum uric acid （SUA）level,brachial-ankle pulse wave velocity （baPWV）and severity of coronary disease.Methods：A total of 121 inpatients,who hospitalized in our department of cardiology from Jan 2011 to Jul 2012,were enrolled.According to results of coronary angiography,they were divided into coronary heart disease （CHD）group （n=59）and normal control group （n=62）,CHD group was further divided into single vessel coronary disease group （n=30,single vessel group）,double-vessel coronary disease group （n=14,double-vessel group）and multi-vessel coronary disease group （n=15,multi-vessel group）.SUA level and baPWV were compared among all groups,and their relationship with degree of coronary disease was analyzed. Results：SUA concentration gradually rose along with number of diseased coronary vessels increased,it＇s （349.26± 96.58）μmol/L,（400.37±70.96）μmol/L,（517.57±85.26）μmol/L and （602.60±77.03）μmol/L in normal control,single vessel,double-vessel and multi-vessel group respectively,P〈0.05 or 〈0.01;baPWV gradually rose a-long with number of diseased coronary vessels increased,compared with normal control group,there was significant increase in baPWV [（1499.04±193.82）cm/s vs.（1885.32±319.73）cm/s,（2036.00±406.40）cm/s,（2171.03± 348.53）cm/s]in single vessel,double-vessel and multi-vessel group,that of double-vessel group was significantly higher than that of single vessel group,P〈0.05-〈0.01.Logistic regression analysis indicated that SUA and baPWV were independent risk factors for CHD morbidity （OR=13.011,14.008,P=0.000）.Conclusion：Serum uric acid level and pulse wave velocity possess important clinical application value for predicting CHD and its severity.