新疆维、哈族冠心病患者降低低密度脂蛋白-胆固醇疗效的比较

Comparison of therapeutic effect lowering low density lipoprotein cholesterol in Uygur and Kazak nationality patients with coronary heart disease from Xinjiang

目的：对比明确诊断为冠心病的维、哈族患者治疗前后的低密度脂蛋白胆固醇（LDL-C）水平，进一步指导临床治疗。方法：对首次入院行冠脉造影检查并明确诊断为冠心病的维族（191例）、哈族（184例）患者测定其LDL-C浓度，并给予冠心病二级预防治疗8-12个月，住院后再次测定LDL-C浓度，并行统计学比较分析。结果：治疗后维、哈两族冠心病患者 LDL-C水平均有显著降低，且维族冠心病患者较哈族LDL-C [（2.21±0.17）mmol/L比（2.74±0.13）mmol/L]水平降低得更显著（t＝3.141，P＜0.01）。结论：维族冠心病患者低密度脂蛋白水平降脂的疗效显著好于哈族。

Objective：To compare the level of low density lipoprotein cholesterol （LDL-C）before and after treatment between Uygur and Kazak nationality patients diagnosed as coronary heart disease （CHD）.Methods：A total of 191 Uygur nationality patients and 184 Kazak nationality patients,who received coronary angiography and were diagnosed as CHD first time, and received measurement of LDL-C concentration.They received CHD secondary preventive treatment for 8-12 months,LDL-C concentration was measured again after treatment,and it＇s compared and analyzed between two nationalities.Results：After treatment,there were significant reductions in levels of total cholesterol （TC）and LDL-C in Uygur and Kazak nationality CHD patients.Compared with Kazak nationality patients,there were significant reductions in levels of LDL-C [（2.74±0.13）mmol/L vs.（2.21±0.17）mmol/L]in Uygur nationality CHD patients （t=3.141,P〈0.01）.Conclusion：Effect lowering in Uygur nationality patients with coronary heart disease ,especially low density lipoprotein cholesterol is better than that of Kazak nationality.