阿托伐他汀联合曲美他嗪治疗不稳定型心绞痛的疗效

Therapeutic effect of atorvastatin combined trimetazidine on treating unstable angina pectoris

目的:研究阿托伐他汀(ATO)联合曲美他嗪(TRZ)对不稳定型心绞痛(UAP)的疗效。方法:选择2011年3月到2013年3月在我院被确诊为UAP的患者100例。以数字法随机分为ATO组(常规药物治疗基础上加入ATO,50例),ATO+TRZ组(在ATO组基础上另加用TRZ,50例)。对比两组疗效及治疗前后血脂水平情况。结果:ATO+TRZ组,总有效率为96.00%(48/50),显著高于ATO组的76.00%(38/50)(P<0.05)。治疗后两组血脂水平均有显著改善,与ATO组比较,ATO+TRZ组总胆固醇[TC,(4.78±0.65)mmol/L比(4.12±0.60)mmol/L]、甘油三酯[TG,(1.54±0.51)mmol/L比(1.02±0.53)mmol/L]及低密度脂蛋白-胆固醇[LDL-C,(3.02±0.46)mmol/L比(2.32±0.45)mmol/L]水平显著降低,高密度脂蛋白胆固醇[HDL-C,(1.57±0.58)mmol/L比(2.12±0.55)mmol/L]显著升高,差异均有统计学意义(P均<0.05)。结论:阿托伐他汀与曲美他嗪联合治疗不稳定型心绞痛患者,疗效更显著,值得临床推荐。

Objective：To study the therapeutic effect of atorvastatin （ATO）combined trimetazidine （TRZ）on unstable angina pectoris （UPA）.Methods：A total of 100 UAP patients in our hospital from Mar 2011 to Mar 2013 were enrolled.According to number table method,they were randomly divided into ATO group （received ATO additionally based on routine medication,n=50）and ATO＋TRZ group （received TRZ additionally based on ATO group treatment,n=50）.Levels of blood lipids and therapeutic effects were compared between two groups before and after treatment.Results：Total effective rate was 96.00% （48/50）in ATO＋TRZ group,which was significantly higher than that of ATO group （76.00%）,P〈0.05.Compared with ATO group,there were significant reductions in levels of total cholesterol [TC,（4.78±0.65）mmol/L vs.（4.12±0.60）mmol/L],triglyceride [TG, （1.54±0.51）mmol/L vs.（1.02±0.53）mmol/L]and low density lipoprotein cholesterol [LDL-C,（3.02±0.46） mmol/L vs.（2.32±0.45）mmol/L],and significant rise in level of high density lipoprotein cholesterol [HDL-C, （1.57±0.58）mmol/L vs.（2.12±0.55）mmol/L]in ATO＋TRZ group,P〈0.05 all.Conclusion：Atrovastatin combined trimetazidine can more significantly improve therapeutic effect in patients with unstable angina pectoris, which should be recommended in clinic.