262例慢阻肺合并肺部感染患者痰培养与耐药性分析

Sputum culture and drug resistance analysis in 262 cases chronic obstructive pulmonary disease with pulmonary infection

目的:分析慢性阻塞性肺病(COPD)合并肺部感染患者分离致病菌菌群分布及耐药性。方法:对262例COPD合并肺部感染患者痰标本作病原菌分离培养和耐药性分析。结果:262例患者中分离出227株病原菌,142株为革兰阴性菌感染,66株为革兰阳性球菌感染,19株为真菌感染。药敏结果显示:革兰阴性杆菌对亚胺培南等较为敏感,革兰阳性球菌对万古霉素敏感性较高,真菌中白色念珠菌对氟康唑较为敏感;革兰阴性杆菌中产β-内酰胺耐药性为主。结论:COPD合并肺部感染患者应根据药敏试验结果,合理选用抗菌药物,减少耐药菌产生,降低患者病死率。

Objective：To analyze the patients with chronic obstructive pulmonary disease （COPD） with lung infec-tion separation of pathogenic bacteria flora distribution and drug resistance. Methods：262 patients with COPD pul-monary infection sputum specimens for pathogen separation cultivation and drug resistance analysis. Results 262 cases of COPD patients isolated 227 strains of pathogenic bacteria, 142 strains of gram-negative bacteria infection, 66 strains of gram-positive cocci infection, 19 strains of fungal infection. Drug susceptibility results showed that gram negative bacillus was sensitive to imipenem, and gram-positive cocci was sensitive to vancomycin, the fungus of candida albicans was sensitive to fluconazole;Gram-negative bacillus middle beta lactam resistance is given priority to. Conclusion：Pulmonary infection with COPD in patients should be according to the results of drug sensitive test, a reasonable choice of antimicrobial agents, reduce the resistant bacteria produce and mortality.