血浆 TGF -β1对非小细胞肺癌（NSCLC）放射性肺损伤的预测价值

The predictive value of plasma TGF-β1 in radiation -induced lung injury for non -small cell lung cancer（NSCLC）

放疗在肺癌治疗中占有重要地位，在放疗中放射性肺损伤是治疗过程中的主要并发症，如何在临床治疗中早期预测放射性肺损伤的发生，对于疾病的治疗及预后具有重大意义。 TGF-β1（ Trans-forming growth factor-β1）可诱导炎性细胞包括淋巴细胞、中性粒细胞、单核细胞等促使纤维化的形成，采血检测发现放疗后发生放射性肺损伤的患者中，在放疗不同时期血浆TGF-β1表达水平发生变化，因此本文从细胞因子TGF-β1着手，综述了其单独、联合放射物理、其他细胞因子、基因等多方面探讨其在预测放射性肺损伤方面的价值。

Radiotherapy plays an important role in the treatment of lung cancer .Radiation-induced lung injury is a major complication in the process of radiotherapy .It is of great significance for the treatment and prog-nosis of the diseases to predict the early stage of radiation -induced lung injury in the clinical treatment .TGF-β1（transforming growthfactor-β1） can induce some inflammatory cells including lymphocytes ,neutrophils,mon-ocytes ect,contributing to the formation of fibrosis .Plasma TGF-β1 shows different levels followed different sta-ges of radiation-induced lung injury .This article reviews the value of cytokine TGF -β1 in predicting the radia-tion-induced lung injury over various aspects such as singlely used ,combined with radiation physics and other cytokines,and genomics.