献血者感染丙型肝炎影响因素的病例对照研究

Case Control Study of Influencing Factors on Blood Donors Infected With HCV

目的研究探讨共用剃刀等危险因素与丙型肝炎传播的关系。方法对311名单纯抗-HCV检测为阳性的献血者及622名阴性献血者进行病例对照研究,应用多因素条件Logistic回归模型分析与感染因素,研究发现使用共用剃刀、牙科治疗史、住院史、乙肝家族史、输血史等可以增加HCV感染的危险性,其危险度(OR)分别是:2.080、2.380、2.176、2.438和7.177,人群归因危险度分别是:15.30%、25.66%、10.60%、3.03%和1.84%,5项危险因素总的人群归因危险度为46.08%结论共用剃刀以及可能导致血液接触的器具是丙型肝炎传播的危险因素。

Objective To explore the relationship of razor - sharing and the transmission of hepatitis C virus （HCV） among volunteer blood donors in Chengdu. Methods An amount of 311 blood donors with positive anti- HCV, and other 622 negative blood donors were conducted case control study. Participants in the two groups were compared with logistic regression. Results According to the multiple condition logistic regression model, razor shared, dental care, hospital admission, family history of hepatitis B, blood transfusion in- creased the risk of HCV infection, the OR values were 2. 080, 2. 380, 2. 176, 2. 438 and 7. 177, respec- tively; population attributable risks （PAR） were respectively 15.30%, 25.66%, 10. 60%, 3.03% and 1.84% ; the total PAR was 46. 08%. Conclusion The razor - sharing and possible contaminated instruments used by others are risk factors for hepatitis C infection.