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心肌梗死中微小RNA的研究进展及临床应用前景 被引量：9

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摘要 心肌梗死是工业化国家人口死亡的最主要的原因之一，虽然目前针对心肌梗死有一系列有效的治疗方法，但心肌梗死患者仍存在较高的死亡率和并发症，如心律失常、心力衰竭，因此探索出新的心肌梗死治疗方法是极其重要的。
作者 余华东 佘强
机构地区 重庆医科大学附属第二医院心内科
出处 《重庆医学》 CAS CSCD 北大核心 2014年第19期2514-2517,共4页 Chongqing medicine
基金 国家自然科学基金资助项目(NSFC81270211 NSFC81100088) 高等学校博士学科点专项科研基金资助项目(20125503110009) 重庆教委科学技术研究项目(KJ130324)
关键词 微小RNA 心肌梗死 心律失常 心肌纤维化
分类号 R542.22 [医药卫生—心血管疾病]
  • 相关文献

参考文献25

  • 1Yang BF, Lin HX, Xiao J N, et al. The muscle-specific mi croRNA miR-1 regulates cardiac arrhythmogenic potential by targeting GJA1 and KCNJ2[J]. Nature Med, 2007,13 (4) :486-491.
  • 2Tang Y, Zheng J, Sun J, et al. MieroRNA-1 regulates car- diomyocyte apoptosis by targeting Bcl-2[J]. Int Heart J, 2009,50(3) :377-387.
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  • 4Xu C,Lu Y,Pan Z,et al. The muscle-specific microRNAs miR-1 and miR-133 produce opposing effects on apoptosis by targeting HSP60, HSP70 and caspase-9 in cardiomyo- eytes[J]. J Cell Sci, 2007,120(Pt 17) : 3045-3052.
  • 5Duisters RF, Tijsen AJ, Schroen B, et al. miR-133 and miR-30 regulate connective tissue growth factor: Imlpli cations for a role of microRNAs in myocardial matrix re- modeling[J]. Circ Res, 2009,104 (2) : 170-178.
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同被引文献124

  • 1苏晓叶,刘志忠,李小波,吴俊,陈绍良.不同剂量的阿托伐他汀对心肌损伤大鼠内皮祖细胞动员及血管内皮功能的影响[J].中国动脉硬化杂志,2007,15(4):277-280. 被引量：10
  • 2刘尊齐,崔连群,盖玉生,李峰.大鼠急性心肌梗死模型的制备[J].基础医学与临床,2007,27(9):1059-1060. 被引量：18
  • 3Hojo Y,Ikeda U,Ueno S,et al. Expression of matrix metalloproteinasesin patients with acute myocardial infarction [ J]. Jpn Circ J,2001 ,65?2):71-75.
  • 4Cai B,Pan Z,Lu Y,et al. The roles of microRNAs in heart diseases:a no-vel important regulator [J]. Curr Med Chem,2010,17(5) :407-411.
  • 5Yin C, Wang X, Kukreja RC. Endogenous microRNAs induced byheat-shock reduce myocardial infarction following ischemia-reperfusionin mice [J]. FEBS Lett,2008,582(30) :41374142.
  • 6Wang R, Li N, Zhang Y, et al. Circulating microRNAs are promis- ing no,Jel biomarkers of acute myocardial iafarction [ J 1. Intern Med,201 1,50( 17 ) : 1789-1795.
  • 7Yang B, Lin H, Xiao J,et al. The muscle-specific microRNA miR-I regulates cardiac arrhythmogenic potential by targeting GJA1 and KCNJ2[ J]. Nat Med,2007,13(4) :486-491.
  • 8Li Q, Song X W, Zou J, et al. Attenuation of mlcroRNA-I dere- presses the cytoskeleton regulatory protein twinfifin-1 to provoke cardiac hypertrophy[J]. J Cell Sci ,2010,123 ( 14 ) :2444-2452.
  • 9Lu Y,Zhang Y, Shan H,et al. MicroRNA-1 downregulation by pro- pranolol in a rat model of myocardial infarction : a new mechanism for ischaemic eardioprotection [ J ]. Cardiovasc Res, 2009,84 ( 3 ) : 434-441.
  • 10Cheng Y,Tan N,Yang J, et al. A translational study of circulating cell-free microRNA-1 in acute myocardial infarction [ J ]. Clin Sci ( Lond) ,2010,119(2):87-95.

引证文献9

二级引证文献45

重庆医学
2014年 第19期

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