尼莫地平减少面神经微血管减压术后面听神经相关并发症的作用

Effects of nimodipine on reducing the complications after microvascular decompression in patients with hemifacial spasm

目的:探讨尼莫地平是否能减少面肌痉挛微血管减压术后面听神经相关并发症。方法:选择2011年5月至2013年10月期间,因面肌痉挛于我科行面神经微血管减压术患者220例,随机分为两组,治疗组110例,术后当日开始静脉泵入尼莫地平注射液(尼膜同)50 mg,泵速:2 mg/h,疗程3 d。3 d后改为口服尼莫地平片剂30 mg,每天3次,疗程1周。对照组110例,术后不应用尼莫地平,其余治疗均与治疗组相同。统计两组患者术后3个月内面听神经并发症周围性面瘫及听力下降的发生情况并进行分析。结果:两组病例面肌痉挛治疗有效率均为100%,尼莫地平组术后周围性面瘫及听力下降的发生率较对照组降低(P<0.05)。结论:尼莫地平可显著降低面神经微血管减压术后周围性面瘫及听力下降的发生率。

Objective To investigate whether nimodipine could reduce complications after microvascular decompression in patients with hemifacial spasm. Methods 220 patients with hemifacial spasm, admitted into our hospital from May 2011 to Oct. 2013, were all treated by microvascular decompression. They were divided randomly into two groups. Patients in the treatment group were treated with nimotop 50 mg/d after the operation for the first 3 days, then was orally taken 30 mg/d for a week. Patients in the control group were treated with the same after the operation without nimodipine. The postoperative complications including hearing deficit and peripheral facial paralysis were closely observed within three months after operation. Results The total effective rate was 100% in both groups. The incidence rate of peripheral facial paralysis and hearing deficit in treatment group was significant lower than that of the control group （P 〈 0.05）. Conclusion Nimodipine has significant effect on reducing the incidence rate of peripheral facial paralysis and hearing deficit after microvascular decompression in patients with hemifacial spasm.